Abstract Library

#3651 Mesenteric fibrosis in small intestinal neuroendocrine tumors (SI-NETs) – Steps towards understanding its pathogenesis

Introduction: Mesenteric fibrosis (MF) occurs in 50% of patients with SI-NETs, causing significant morbidity and mortality. The pathogenesis of MF in SI-NETs is incompletely understood with no biomarkers or radiological criteria to predict long-term complications of SI-NET associated MF.

Conference:

Presenting Author:

Authors: Hodgetts H, Martins M, Luong T, Hall A, Thirlwell C,

Keywords: small, intestine, neuroendocrine tumor, fibrosis, mesenteric, rna-sequencing, biomarker,

#2269 Can Insulin-Like Growth Factor 1 (IGF-1), IGF-1 Receptor, Connective Tissue Growth Factor and Ki-67 Labelling Index Have a Prognostic Role in Pulmonary Carcinoids?

Introduction: Altered expression of Insulin-like Growth Factor-1 (IGF-1), its receptor (IGF-1R), Connective Tissue Growth Factor (CTGF) and Hypoxia Factor-1 (HIF-1), has been implicated in tumorigenesis. These factors have not been studied systematically in Pulmonary Carcinoids (PCs).

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Tsolakis A, Kanakis G, Grimelius G, Papaioannou D, Kaltsas G,

Keywords: IGF-1, IGF-1R, CTGF, HIF-1, Ki-67,

#1886 Effect of Treatment with Prolonged-Release Somatostatin Analogues on the Concentration of Serum Fibrosis Markers in Patients with Carcinoid Syndrome.

Introduction: A fibrosis is a major local and/or distant complication of neuroendocrine tumours (NETs) of the small intestine secreting serotonin. Tumour cells produce connective tissue growth factor CTGF and transforming growth factor TGFα and TGFβ which locally stimulate fibrosis and cause distant fibrosis.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Foltyn W, Zemczak A, Rosiek V, Kilian-Kita A, Kos-Kudła B,

Keywords: fibrosis,CTGF,TGFβ,carcinoid syndrome,

#911 Immunohistochemical Expression of Connective Tissue Growth Factor and Insulin-like Growth Factor-1 in Lung Carcinoids

Introduction: Several studies have shown altered expression of Insulin-like Growth Factor-1 (IGF-1) and its receptor (IGF-1R) in different types of cancers. Connective Tissue Growth Factor (CTGF) is triggered by Serotonin (5-HT) and Hypoxia Induced Factor 1 (HIF-1) and has been associated with tumor expansion and desmoplastic reaction in carcinoid tumors.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Kanakis G, Grimelius L, Kaltsas G, Tsolakis A,

Keywords: lung, carcinoid, CTGF, IGF-1,

#908 Role of Epithelial-to-Mesenchymal Transition Markers in Predicting Bone and Visceral Metastases from NETs

Introduction: Epithelial-to-mesenchymal transition (EMT) of tumor cells has been recently postulated as a pivotal mechanism driving metastatic spread.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Cives M

Authors: Simone V, Cives M, Rizzo F, Bisceglia F, Savonarola A,

Keywords: EMT, biomarker,