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#3345 Integrative molecular analysis of combined small-cell lung carcinoma reveals EGFR and KRAS mutational analysis as the theragnostic tools in whole small cells lung carcinoma landscape

Introduction: Combined small-cell lung cancer (C-SCLC) are composed of SCLC admixed with a non-small-cell cancer component. They currently receive the same treatment as SCLC. The recent evidence that SCLC may belong to either of 2 lineages, neuroendocrine or non-neuroendocrine, with different vulnerability to specific cell death pathways such as ferroptosis, opens new therapeutic opportunities also for C-SCLC.

Conference:

Presenting Author:

Authors: Simbolo M, Centonze G, Ali G, Ciaparrone C, Grillo F,

Keywords: Combined small cell lung carcinoma, small cell lung cancer, neuroendocrine carcinoma, next generation sequencing, transcriptomics,