Abstract Library

#3952 Peptide Receptor Radionuclide Therapy (PRRT) in the management of patients with ectopic Cushing’s syndrome due to metastatic gastroenteropancreatic neuroendocrine neoplasia (GEPNEN): A single centre experience

Introduction: Metastatic GEPNEN can cause ectopic Cushing’s syndrome (ECS). ECS is highly morbid and often refractory to medical therapy. Bilateral adrenalectomy (BA) carries risk and long-term morbidity. Patients (pts) unsuitable for surgery have dismal outcomes. Peptide receptor radionuclide therapy (PRRT) is a rational option for hormone control in ECS caused by NEN with high somatostatin receptor (SSTR) expression yet detailed case series to guide its use are lacking.

Conference:

Presenting Author: Boehm E

Authors: Boehm E, Hung T, Akhurst T, Alipour R, Cardin A,

Keywords: GEPNEN, PRRT, Ectopic Cushing's Syndrome,

#3728 ACTH-secreting pancreatic neuroendocrine neoplasms – A case-series

Introduction: Ectopic Cushing’s syndrome occurs rarely in patients with pancreatic neuroendocrine neoplasms. Early recognition of symptoms is critical given the high morbidity and mortality associated with Cushing’s syndrome.

Conference:

Presenting Author: Al-Toubah T

Authors: Al-Toubah T, Pelle E, Hallanger-Johnson J, Haider M, Strosberg J,

Keywords: pancreatic neuroendocrine neoplasm, Cushing’s syndrome, ACTH, ectopic Cushing’s, neuroendocrine tumor,

#3679 Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine tumor of the ileum

Introduction: Ectopic Cushing syndrome is responsible for 20% of cases of Cushing’s syndrome (CS); with presentation ranging from undetectable lesions to metastatic carcinomas. Ectopic ACTH syndrome (EAS) of intestinal origin is very rare, only five patients have been reported. In this article, we report a case of an ileal ACTH-secreting Neuroendocrine tumor.

Conference:

Presenting Author:

Authors: González Devia D, Llanos-Orozco N, López-Mesa de Mesa J, Fierro-Maya L, Cuéllar-Cuéllar A,

Keywords: Ectopic ACTH syndrome, Midgut Neuroendocrine Tumor, Ectopic Cushing syndrome, Neuroendocrine Tumor, Small intestine tumor,

#3310 Ectopic Cushing’s syndrome: Experience from a tertiary care center

Introduction: Neuroendocrine neoplasms (NENs) causing ectopic Cushing’s syndrome (ECS) are relatively rare and very challenging to treat.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Lase I

Authors: Lase I, Grönberg M, Strele I, Kozlovacki G, Norlën O,

Keywords: Ectopic Cushing’s syndrome, ACTH, neuroendocrine, hypercortisolism, multiple hormone secretion, bilateral adrenalectomy,

#2885 Ectopic Neuroendocrine Carcinoma: An Occult Source of ACTH

Introduction: About 250 cases of ectopic ACTH-producing neuroendocrine carcinoma (ACTH-NEC) have been reported; however metastatic ACTH-NEC of unknown primary is very rare. Usually are characterized by having a large cell, small cell, poorly differentiated or anaplastic cell, and Ki-67 index between 40-90%.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Huertas Gnecco B

Authors: Huertas Gnecco B, González Devia D, Alvaréz Figueroa J, Aguirre Matallana D, Cañón Solano D,

Keywords: Ectopic ACTH production, Cushing’s syndrome, Neuroendocrine carcinoma, Paraneoplastic Cushing syndrome, Ectopic Cushing´s syndrome,