Abstract Library

#4057 Neuroendocrine neoplasms in the young: The experience of a single-centre study

Introduction: The incidence of neuroendocrine tumours (NET) is steadily increasing (6.98 per 100000 inhabitants). In Italy, cancer is the second cause of mortality in young patients.

Conference:

Presenting Author: Cannavale G

Authors: Cannavale G, Benevento E, Liccardi A, Minotta R, Di Iasi G,

Keywords: Neuroendorine tumor, NET, young patients, single-centre case series, epidemiology,

#3952 Peptide Receptor Radionuclide Therapy (PRRT) in the management of patients with ectopic Cushing’s syndrome due to metastatic gastroenteropancreatic neuroendocrine neoplasia (GEPNEN): A single centre experience

Introduction: Metastatic GEPNEN can cause ectopic Cushing’s syndrome (ECS). ECS is highly morbid and often refractory to medical therapy. Bilateral adrenalectomy (BA) carries risk and long-term morbidity. Patients (pts) unsuitable for surgery have dismal outcomes. Peptide receptor radionuclide therapy (PRRT) is a rational option for hormone control in ECS caused by NEN with high somatostatin receptor (SSTR) expression yet detailed case series to guide its use are lacking.

Conference:

Presenting Author: Boehm E

Authors: Boehm E, Hung T, Akhurst T, Alipour R, Cardin A,

Keywords: GEPNEN, PRRT, Ectopic Cushing's Syndrome,

#2944 Soluble ST2 (sST2) Levels in the Management of Carcinoid Heart Disease in Patients with Neuroendocrine Cancer

Introduction: The identification of a sensitive biomarker to detect the presence and severity of carcinoid heart disease could allow more selective use of clinical and echocardiographic screening. ST2 is a protein belonging to the family of interleukin 1 receptors, present both in the isoform of transmembrane (ST2L) and in the soluble one (sST2). sST2 blocks the anti-inflammatory, anti-hypertrophic, and anti-fibrotic effects of cytokine IL-33 on the myocardium and recent studies have shown that sST2 levels increase in the blood of patients diagnosed with heart failure.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Salvatici M, Zorzino L, Fabiani I, Cardinale D, Fazio N,

Keywords: sST2, Biomarkers, Carcinoid Heart Disease,

#988 Vimentin and E-cadherin Expression in Primary Neuroendocrine Tumors by Grade

Introduction: The prognostic evaluation of radically removed neuroendocrine tumors (NETs) represents an important issue. The cardinal tumor features can be studied as biomarkers.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Vanags A, Strumfa I, Simtniece Z, Vasko E, Gardovskis J,

Keywords: NETs, vimentin, E-cadherin,