Abstract Library

#4237 Continuing Somatostatin Analogues Upon progression in Neuroendocrine tumor pAtients (SAUNA trial) – Study protocol for a bi-national, multi-center, open-label, randomised, pragmatic clinical trial

Introduction: Advanced gastroenteropancreatic neuroendocrine tumors (GEP NET) are treated with targeted therapy or peptide receptor radionuclide therapy (PRRT) (177Lu-DOTATATE) upon progression under somatostatin analogues (SSA). SSA are continued life-long in functional NET, but the benefit of SSA continuation in non-functional NET is unclear. Due to ongoing activity of the somatostatin receptor pathway in GEP NET progressing on SSA, we hypothesize an added efficacy of SSA during second-line therapy.

Conference:

Presenting Author: Chhajlani S

Authors: Chhajlani S, Kuiper J, Borbath I, Dercksen W, Deroose C,

Keywords: somatostatin analogues, SSA, everolimus, sunitinib, peptide receptor radionuclide therapy, PRRT, quality of life, QoL, gastroenteropancreatic neuroendocrine tumor, GEP NET,

#2023 International Multicentre Retrospective Study on the Safety of Radioembolization with Yttrium-90 Resin Microspheres after Systemic Radionuclide Therapy in Neuroendocrine Tumors

Introduction: In the treatment metastatic neuroendocrine tumours (mNET) safety concerns exist when treating patients with radioembolization (RE) after prior systemic radionuclide therapy (SRT)

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Braat A

Authors: Braat A, Kappadath C, Ahmadzadehfar H, Stothers C, Deroose C,

Keywords: PRRT, Radioembolization, neuroendocrine tumors, metastasis, radionuclide treatments,

#1683 International Multicenter Retrospective Study on the Efficacy and Toxicity of Radioembolization in Neuroendocrine Tumours with Yttrium-90 Resin Microspheres

Introduction: Radioembolization (RE) is applied worldwide in patients with liver-dominant metastatic neuroendocrine tumours (mNET). Current literature is of poor quality and based on small heterogeneous populations

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Braat A

Authors: Braat A, Mahvash A, Stothers C, Deroose C, Frilling A,

Keywords: neuroendocrine tumors, radioembolization, sirt,

#153 Antibody formation against somatostatin analogues with altered biodistribution and dosimetry: a case with implications for PRRT

Introduction: Peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs) has emerged as a powerful palliative therapy. I.v. administration of radiolabeled (e.g. Yttrium-90) somatostatin analogues (SA) results in high-dose local irradiation of all tumor sites. The radiolabelled SA accumulates in the tumors through receptor-mediated internalization depending on the expression of somatostatin receptors and the pharmacokinetics of the radiolabelled SA.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: VAN BINNEBEEK S

Authors: Van Binnebeek S, DeRoose C, Van Billoen B, Baete K, Mortelmans L,

Keywords: antibody, somatostatin analogue, 90Y-DOTATOC, dosimetry, PRRT, 68Ga-DOTATOC,