Abstract Library

#4497 Complex management of a long-term gastrinoma survivor with multimodal treatment approaches

Introduction: The prognosis of pancreatic gastrinomas is influenced by tumour burden, extent of metastasis, and treatment response, with 5-year survival rates ranging from 20% to 40%. Treatment for well-differentiated tumours typically include locoregional therapies, long-acting somatostatin analogues, molecular targeted agents, radionuclides, and chemotherapy.

Conference:

Presenting Author: Puscasu A

Authors: Puscasu A, Miron M, Croitoru A,

Keywords: gastrinoma, neuroendocrine tumour, long survival, complex management,

#4445 Pancreatico-duodenal gastrinomas: Surgical management and late results – 50 years' experience in a single centre

Introduction: Gastrinomas are one of the less frequent and elusive variety of neuroendocrine tumours (NET) of the upper digestive tract and pancreas, clinically expressed with a Zollinger-Ellison syndrome (ZES), possibly associated to a Multiple Endocrine Neoplasia type 1 (MEN1).

Conference:

Presenting Author:

Authors: Milanetto A, Veronese E, de Carlo E, Pasquali C,

Keywords: gastrinoma, men1, net,

#4096 Co-production of patient information: A model for today’s practice

Introduction: According to the British Medical Association, good quality patient information is fundamental to effective, patient-centred, quality care. It rightly considers patients as partners in their care, “Co-production involves engaging groups of people who use healthcare services, in equal partnership; at the earliest stages of service design, development and evaluation. It acknowledges that people with ‘lived experience’ of a particular condition are often best placed to advise on what support and services will make a positive difference to their lives.” (NHS England) The re-introduction of a liver transplantation programme in the UK for selected patients with a Neuroendocrine Neoplasm offers new opportunities to improve survival and quality of life: good quality information is a key tool for informed consent.

Conference:

Presenting Author:

Authors: Jervis N, Ellis C, Smith S, Shah T, Lewis K,

Keywords: Liver Transplantation, Co-production, Patient Information, Lived Experience Contribution,

#4093 Evaluation of the utility of group therapy as a mechanism of delivering facilitated psychosocial support to those with a neuroendocrine neoplasm diagnosis

Introduction: Anxiety, uncertainty and reduced psychosocial well-being have been reported in those with neuroendocrine neoplasms. There has been an increasing demand for facilitated psychosocial support from our UK community, that can outstrip capacity. There is evidence that group therapy can provide a cost- efficient and outcome- effective method of treatment: reducing wait times and improving accessibility. Group therapy is a term that can be applied to any kind of psychotherapy that is delivered to a group.

Conference:

Presenting Author: Hargreaves R

Authors: Jervis N, Winter K, Hargreaves R, Ellis C,

Keywords: Group Therapy, Unmet Needs, Psychosocial Support,

#3608 Endoscopic ultrasound fine-needle biopsy to assess DAXX/ATRX expression and alternative lengthening of telomeres status in non-functional pancreatic neuroendocrine tumors

Introduction: Death domain-associated protein (DAXX) and/or α-thalassemia/mental retardation X-linked (ATRX) chromatin remodelling genes mutations and alternative lengthening of telomeres (ALT) activation are associated with more aggressive behaviour of non-functional pancreatic neuroendocrine tumors (NF-pNETs).

Conference:

Presenting Author:

Authors: Mastrosimini M, Manfrin E, Remo A, de Bellis M, Pedron S,

Keywords: pancreatic tumor, ALT, FISH, immunohistochemistry,