#4373
Focal adhesion kinase drives proliferation and invasion in gastrointestinal neuroendocrine tumours via modulation of transformative cell signalling and gene expression
Introduction:
Focal Adhesion Kinase (FAK) is a non-receptor protein kinase that localises in both the cytoplasm and nucleus, influencing cell function through its enzymatic and scaffold activities. Through its scaffold function, FAK modulates gene expression epigenetically. Gastrointestinal neuroendocrine tumours (GI-NETs) exhibit a relatively low mutation rate, supporting the hypothesis that these malignancies may be driven epigenetically. Recently, PROTAC (PROteolysis TArgeting Chimeras) technology has enabled selective inhibition and degradation of FAK, providing a novel approach to explore its role in GI-NETs.
Conference:
Presenting Author:
Gagliano T
Authors:
Toffoli L,
Ditsiou A,
Moschioni E,
Hamm V,
Gagliano T,
Keywords:
FAK,
GI-NET,
Cell Signalling,
Epigenetics,
#3987
m6A modifications promote the invasion and metastasis of pancreatic neuroendocrine neoplasms by activating the Integrin/FAK signalling pathway via TGFBI
Introduction:
Nearly 50% of patients with pNENs have metastases at the time of initial diagnosis, and there is a lack of effective treatment once they have metastases. The 5-year overall survival rate for G3 pNENs with metastasis at diagnosis was 0, which was significantly lower than that for patients without metastasis, with a 5-year overall survival rate of 43%. At present, the pathogenesis of pNENs has not been clarified.
Conference:
Presenting Author:
Authors:
Ye M,
Tang Q,
Keywords:
RNA methyltransferases,
Tumor metastasis,
Pancreatic neuroendocrine neoplasm,
Transforming growth factor-β-induced gene,
Integrin/FAK signaling pathway,
