Abstract Library

#4431 Systemic treatment in metastatic pheochromocytomas and paragangliomas: Optimal moment for starting and outcomes of a multicentre Spanish cohort

Introduction: Pheochromocytomas (PHEOs) and paragangliomas (PGLs), collectively referred to as PPGLs, are relatively rare endocrine tumours with significant clinical variability and metastatic behaviour. Treatment strategies must be tailored individually due to the heterogeneity in their behaviour.

Conference:

Presenting Author: Del Olmo-García M

Authors: Hernández-Rienda L, Contreras-Saldarriaga J, Hernando Cubero J, García Alvarez A, Prado-Wohlwend S,

Keywords: Pheochromocytoma, paraganglioma, PPGL, metastatic, SSA, Radionuclide, chemotherapy,

#4386 Streptozotocin- and temozolomide-based chemotherapy treatment in neuroendocrine neoplasms – Efficacy in patients treated outside clinical trials

Introduction: Chemotherapy treatment based on alkylating agents is useful in pancreatic and grade 3 neuroendocrine neoplasms (NENs). However, no current real-life data is available comparing streptozotocin (STZ) and temozolomide (TEM) combinations.

Conference:

Presenting Author: García-Álvarez A

Authors: García Alvarez A, Martínez-Badal S, García-Burillo A, Simó Perdigo M, Merino Casabiel X,

Keywords: Streptozotocin, temozolomide, neuroendocrine neoplasm,

#4352 What can a reference centre offer to patients? Evolution of first visits for neuroendocrine and endocrine tumours and its relation to clinical trials availability.

Introduction: Endocrine and neuroendocrine neoplasia (NEN), which include gastroenteropancreatic neuroendocrine tumours, thyroid cancer and adrenal carcinoma, have a low incidence, making their diagnosis and treatment difficult. Due to this complexity, patients should be managed at specialised centres; however, the lack of official referral networks complicates the concentration of cases.

Conference:

Presenting Author: Martinez-Badal S

Authors: Martínez-Badal S, Hernando Cubero J, García Alvarez A, Elguero B, Alcantara A,

Keywords: Neuroendocrine, Clinical Trial, Reference Centre, Patient referral,

#4077 The importance of pathological sample review in the initial workup study in reference centers: The experience of an ENETS Center of Excellence

Introduction: Neuroendocrine neoplasms (NEN) are complex tumors managed in specialized centers with a multidisciplinary approach. Patients often provide diagnostic studies, including histological material. Pathology department review ensures proper classification, guiding therapies, and potential clinical trial inclusion.

Conference:

Presenting Author:

Authors: Gutierrez Gordo M, Garcia Alvarez A, Hernando J, Landolfi S, Sansano I,

Keywords: Neuroendocrine neoplasm, multidisciplinary, histological review, reference center,

#3862 DLL3 determination and immune milieu characterization in Neuroendocrine Neoplasms (NENs)

Introduction: High DLL3 expression in NENs may be used to activate the immune system by redirecting T cells via bispecific T cell engager (BITE) antibodies.

Conference:

Presenting Author:

Authors: Garcia Alvarez A, Serna G, Hernando Cubero J, Napoli S, Carmona Alonso A,

Keywords: Neuroendocrine, DLL3, Immunotherapy,