Abstract Library

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#1425 Dosimetry to Estimate the Effect of Gelofusine® on the Renal Absorbed Dose of Lutetium 177-DOTA-octreotate.

Introduction: Lutetium-177 DOTA-octreotate (LuTate), a radiolabelled somatostatin analogue, delivers targeted radiation to neuroendocrine tumours and metastases. Healthy tissues also receive significant irradiation. Charged amino acids are routinely co-infused to block renal proximal tubular LuTate reabsorption. Gelofusine® (a succinylated bovine gelatin molecule), proposed to interact with the megalin/cubulin receptor-mediated transporter system, has been shown to reduce renal uptake of indium-111 octreotide. Routine Gelofusine® administration is limited by risk of allergic reaction.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Lucas C, Goodman S, Smith J, Burge M, Wyld D,

Keywords: lutetium, dosimetry, renal, gelatin, somatostatin,

#871 Success with Lutetium-177 DOTATATE Therapy in Cushing’s Syndrome Caused by Functional Pancreatic Neuroendocrine Tumor (pNET) with Ectopic Adrenocorticotropic Hormone (ACTH) Secretion Refractory to Concomitant Everolimus, Pasireotide and Metyrapone

Introduction: We report a case of a 59-year-old female presenting with florid ACTH-dependent Cushing’s syndrome complicated by pulmonary cryptococcal infection.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Chan B, Wyld D, Burge M, Cuneo R, Macfarlane D,

Keywords: pancreatic, neuroendocrine, tumor, ACTH, everolimus, pasireotide, lutetium,

#289 Gallium-68 DOTATATE PET CT Frequently Changes Patient Management or Staging When Compared with Indium-111 Octreotide in the Assessment of Neuroendocrine Tumors

Introduction: 68Ga-DOTATATE PET CT offers higher resolution than previous octreotide-labelled scintigraphic techniques, and the literature suggests increased sensitivity for the localization and staging of NETs.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Carroll R, Comminos A, Frilling A, Meeran K, Al-Nahhas A,

Keywords: Gallium-68 DOTATATE PET CT, Indium-111 Octreotide, neuroendocrine tumor,