Abstract Library

#4550 The relationship between MEN1 germline mutations and SSTR2 expression in neuroendocrine tumours

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary disease characterised by the development of multiglandular parathyroid disease, pituitary tumours, and duodenopancreatic neuroendocrine tumours (NETs). Germline mutations in the tumour suppressor gene MEN1 are the underlying cause. Somatostatin receptor 2 (SSTR2) is commonly expressed by NETs. However, the expression of SSTR2 in patients with MEN1 remains unclear.

Conference:

Presenting Author: Chi Y

Authors: Sun Y, Tan H, Wang H, Shi S, Dong L,

Keywords: multiple endocrine neoplasia type 1, somatostatin receptor 2, neuroendocrine tumour,

#4503 Duodenopancreatic neuroendocrine tumour in MEN1: Gender difference and survival rates

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is the most common inherited syndrome associated with NET development and metastatic duodenal-pancreatic (DP) NET is the main cause of death.

Conference:

Presenting Author: Liccardi A

Authors: Liccardi A, Roberto M, Cannavale G, Benevento E, Di Iasi G,

Keywords: Multiple endocrine neoplasia type 1, neuroendocrine tumour, gender difference, survival,

#4465 RET Lys666Asn has low MEN2-related tumours penetrance but may be associated with pheochromocytoma

Introduction: Multiple Endocrine Neoplasia type 2 (MEN2) is caused by germline pathogenic variants (PVs) in the RET proto-oncogene, leading to medullary thyroid carcinoma (MTC), pheochromocytoma, and primary hyperparathyroidism (PHPT). RET c.1998G>C, p.Lys666Asn is a rare PV, with 33 cases described thus far, and is associated with low penetrance of MEN2-related tumours, but its clinical significance remains incompletely understood.

Conference:

Presenting Author: Halperin R

Authors: Halperin R, Peshes-Yaloz N, Tirosh A, Twito O,

Keywords: MEN2, pheochromocytoma, hyperparathyroidism, medullary thyroid carcinoma,

#4445 Pancreatico-duodenal gastrinomas: Surgical management and late results – 50 years' experience in a single centre

Introduction: Gastrinomas are one of the less frequent and elusive variety of neuroendocrine tumours (NET) of the upper digestive tract and pancreas, clinically expressed with a Zollinger-Ellison syndrome (ZES), possibly associated to a Multiple Endocrine Neoplasia type 1 (MEN1).

Conference:

Presenting Author:

Authors: Milanetto A, Veronese E, de Carlo E, Pasquali C,

Keywords: gastrinoma, men1, net,

#4341 Genetic factors associated with thymic tumours in patients with MEN1: A nested case-control study in the GTE/AFCE cohort of patients with MEN1

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant syndrome due to mutations inactivating the MEN1 gene. It is characterised by the development of tumours in various endocrine tissues. One of the major difficulties in its management is its largely unpredictable course, particularly as regards to the development of thymic tumours, which prognosis remains poor.

Conference:

Presenting Author: Journé A

Authors: Journé A, Goudet P, Sow A, Daniel S, Costa A,

Keywords: thymic tumour, risk factor, Multiple endocrine neoplasia type 1,