Abstract Library

#4360 Real-world practice patterns of 177Lu-DOTATATE in neuroendocrine tumours: A GTE national survey

Introduction: 177Lu-DOTATATE is a standard treatment for neuroendocrine tumours. Grade 3/4 hematologic toxicity affects about 5-10% of patients, with a 2-4% risk of secondary malignant hematologic disorders.

Conference:

Presenting Author:

Authors: Oziel-Taieb S, Ansquer C, Deshayes E, Haissaguerre M,

Keywords: 177Lu-DOTATATE, haematological toxicity, thrombocytopenia, neuroendocrine tumour, toxicity management,

#4355 Emergence of DNA damage repair clonal haematopoiesis after peptide receptor radionuclide therapy for neuroendocrine tumours

Introduction: In neuroendocrine tumours (NETs), PRRT (Peptide Receptor Radionuclide Therapy), has shown efficacy but with significant hematologic toxicity. Clonal haematopoiesis (CHIP) is considered a risk factor for therapy-related myeloid neoplasms (t-MN).

Conference:

Presenting Author: Hadoux J

Authors: Loyaux R, Hadoux J, Oziel-Taieb S, Durand A, Bouhier Leporrier K,

Keywords: PRRT, clonal haematopoiesis, DNA Damage Repair, therapy-related myeloid neoplasm, Neuroendocrine tumour,

#4054 Predictive factors of persistent thrombocytopenia after 177Lu-DOTATATE in patients with neuroendocrine tumors

Introduction: Peptide Receptor Radionuclide Therapy (PRRT) is an effective and well tolerated treatment for advanced Neuroendocrine Tumors (NET). However, some Persistent Thrombocytopenia (PT) are described and may compromise further therapies and outcome.

Conference:

Presenting Author:

Authors: Oziel-Taieb S, Ferrara R, Charrier N, Maniry J, Reichert T,

Keywords: Neuroendocrine Tumor, PRRT, LuDOTATATE, Thrombocytopenia, Bone metastases, spleen,