Abstract Library

#2810 Development of a Personalized Human Immunocompetent Ex-Vivo Model of Neuroendocrine Liver Metastasis Using Precision Cut Tissue Slice Technology

Introduction: Liver metastasis (LM) are very frequent (65-95%) and represent a crucial prognostic factor in patients with gastroenteropancreatic neuroendocrine neoplasms (GEP NENs). The paucity of relevant experimental models has limited the understanding of the pathophysiology of NENs and the development of efficient therapeutic strategies

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Doornebal E

Authors: Doornebal E, Harris N, Miquel R, Zen Y, Pizanias M,

Keywords: Liver, neuroendocrine liver metastasis, ex-vivo model, personalized medicine, immunocompetent, organotypic tissue slices,

#2760 Management and Outcomes of Duodenal Neuroendocrine Tumours

Introduction: Duodenal NENs (D-NENs) are increasing in incidence often incidentally identified at endoscopy. ENETS guidelines suggest endoscopic resection for duodenal NETs <1cm if not periampullary.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Victor A

Authors: Victor A, Pizanias M, Gulati S, Gunasingham N, Ramage J,

Keywords: duodenal NETS, surgical intervention, EMR, ESR, reoccurrence,

#2709 Endoscopic Management and Outcomes of Gastro-Duodenal Neuroendocrine Tumours

Introduction: Gastric and duodenal neuroendocrine tumours are increasing in incidence. ENETS guidelines suggest endoscopic resection of type 1 gastric NENs over 10mm and consider endoscopic resection for duodenal NENs. However, the endoscopic techniques are not clearly mandated. There, is evidence to suggest endoscopic mucosal dissection has higher incidence of R0 resections compared with polypectomy or EMR alone.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Victor A

Authors: Victor A, Pizanias M, Gulati S, Gunasingham N, Ramage J,

Keywords: EMR, ESD, gastric NENS, duodenal NENS,

#2692 Development of Ex-Vivo Models of Metastatic Neuroendocrine Neoplasms

Introduction: The lack of relevant in-vivo and in-vitro models has precluded investigations of the pathophysiology of metastatic NENs. Organotypic tumour slices retain the complexity of tumours in-vivo without extensive manipulation of the tissue.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Srirajaskanthan R

Authors: Srirajaskanthan R, Doornebal E, Harris N, Zen Y, Pizanias M,

Keywords: ex-vivo, organotypic tumour slices, immune environment, models,

#2158 ALPPS as a Technique to Minimize Small For Size Syndrome after Major Hepatectomy for Neuroendocrine Tumour Metastases.

Introduction: Liver resection has emerged as an effective treatment for secondary liver neuroendocrine tumours. “Associated liver partition and portal vein ligation for staged hepatectomy” (ALPPS) allows resection of liver tumours in 2 steps.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Pizanias M

Authors: Pizanias M, Papamichail M, Kontis E, Prassas E, Ramage J,

Keywords: ALPPS, neuroendocrine, hepatectomy,