Abstract Library

#4476 Pancreatic stellate cells promote tumorigenesis and progression of pancreatic neuroendocrine tumours through SERPINE2 and KCNA5

Introduction: Pancreatic stellate cells (PSC) are stromal cells in the pancreas that play a significant role in pancreatic pathology. Nevertheless, few studies have explored the significance of PSC in pancreatic neuroendocrine tumours (panNET). Their contribution to the fibrotic responses in panNET remains poorly understood. How PSC promote tumorigenesis and differentiation in panNET after being activated to myofibroblasts or cancer-associated fibroblasts (CAF) has not been studied.

Conference:

Presenting Author: Tang Q

Authors: Liu J, Li X, Bai J, Tang Q,

Keywords: caf, stellate cell, pan NET, Oncogenes,

#4396 Hypoxic microenvironment in neuroendocrine tumours

Introduction: The hypoxic microenvironment is a hallmark of many solid tumours, including neuroendocrine tumours (NETs). Hypoxia plays a crucial role in tumour progression, metastasis, and therapy resistance. However, the specific mechanisms by which hypoxia influences NET behaviour remain poorly understood.

Conference:

Presenting Author:

Authors: Xu L, Yu P, Ye M, Chen J, Tang Q,

Keywords: Neuroendocrine tumour, hypoxia, HIF-1α, VEGF, mTOR, PI3K/AKT, drug resistance, EMT,

#4382 Sensitivity of endoscopic ultrasound in detecting small gastrointestinal neuroendocrine tumours

Introduction: Small gastrointestinal neuroendocrine tumours (GI-NETs) are often difficult to detect using conventional imaging modalities, leading to delayed diagnosis and suboptimal treatment outcomes. Endoscopic ultrasound (EUS) has emerged as a promising tool for the early detection and precise localisation of these tumours. However, its sensitivity in identifying small lesions remains to be thoroughly evaluated.

Conference:

Presenting Author:

Authors: Xu L, Ye M, Xue B, Tang Q,

Keywords: Endoscopic ultrasound, small gastrointestinal neuroendocrine tumour, early detection, imaging modalities,

#4350 Cytoendoscopy for determining the depth of invasion and metastasis of rectal neuroendocrine tumours

Introduction: Rectal neuroendocrine tumours (rNETs) are relatively common submucosal tumours, but even low-grade rNETs can metastasise. The significance of endocytology (EC) in the clinical evaluation of rNETs has not been reported.

Conference:

Presenting Author: Tang Q

Authors: Bai J, Tian Y, Tang Q,

Keywords: rectal neuroendocrine tumour, cytoendoscopy, invasion, metastasis, tumour grade,

#4319 Everolimus combined with orlistat inhibits the development of neuroendocrine tumours by inhibiting the mTOR-PI3K-Akt signalling pathway

Introduction: Everolimus, an mTOR inhibitor, has demonstrated efficacy in NET treatment. Orlistat, used primarily for obesity management, inhibits fat absorption. This study investigates the potential synergistic effects of Everolimus combined with Orlistat on the development of NETs.

Conference:

Presenting Author:

Authors: Xu L, Tang Q, Ye M,

Keywords: Everolimus, orlistat, mTOR, PI3K/Akt, signalling pathway,