Abstract Library

#3004 Development of Anti-SSTR CAR T Cells for Future Treatment of NETs

Introduction: NETs overexpress somatostatin receptors (SSTRs).

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Cives M

Authors: Mandriani B, Cives M, Pelle' E, Quaresmini D, Ramello M,

Keywords: CAR T cells, adoptive cellular immunotherapy, NETs,

#1847 CXCR4 Inhibition by Ulocuplumab Prevents EMT of pNET Cells in Vitro

Introduction: Neuroendocrine tumors (NETs) overexpress CXCR4. We have previously shown that stimulation of CXCR4 by its ligand SDF-1 promotes the epithelial-mesenchymal transition (EMT) and increases distant tumor spread. Ulocuplumab (Ulo) is a fully human IgG4 mAb designed to inhibit the binding of CXCR4 to SDF-1.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Quaresmini D

Authors: Quaresmini D, Cives M, Pellè E, Ungaro A, Felici C,

Keywords: pNET, CXCR4, EMT, Ulocuplumab,

#1520 Osteotropism of NETs: Role of the SDF1/CXCR4 Axis in Regulating EMT

Introduction: NETs metastasize to the bone in up to 20% of patients. The SDF1/CXCR4 axis is a key determinant of osteotropism, and we showed that NETs overexpressing CXCR4 are more likely to develop bone metastases.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Cives M

Authors: Simone V, Quaresmini D, D'Oronzo S, Rizzo F, Felici C,

Keywords: emt, cxcr4,