Abstract Library
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#1847 CXCR4 Inhibition by Ulocuplumab Prevents EMT of pNET Cells in Vitro
Introduction: Neuroendocrine tumors (NETs) overexpress CXCR4. We have previously shown that stimulation of CXCR4 by its ligand SDF-1 promotes the epithelial-mesenchymal transition (EMT) and increases distant tumor spread. Ulocuplumab (Ulo) is a fully human IgG4 mAb designed to inhibit the binding of CXCR4 to SDF-1.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Quaresmini D
Authors: Quaresmini D, Cives M, Pellè E, Ungaro A, Felici C,
Keywords: pNET, CXCR4, EMT, Ulocuplumab,
#1520 Osteotropism of NETs: Role of the SDF1/CXCR4 Axis in Regulating EMT
Introduction: NETs metastasize to the bone in up to 20% of patients. The SDF1/CXCR4 axis is a key determinant of osteotropism, and we showed that NETs overexpressing CXCR4 are more likely to develop bone metastases.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Cives M
Authors: Simone V, Quaresmini D, D'Oronzo S, Rizzo F, Felici C,
Introduction: Early detection of recurrences is a crucial step in the management of patients (pts) with medullary thyroid carcinoma (MTC). Currently, there is growing interest for PET tracers in MTC such as: 18F-FDG (reflecting glucose metabolism), 18F-DOPA (reflecting amine decarboxylation), 68Ga-somatostatin analogues (reflecting somatostatin receptors expression)
Conference:
Presenting Author:
Authors: Treglia G, Castaldi P, Villani M, Filice A, Ambrosini V,
Keywords: PET/CT; medullary thyroid carcinoma; recurrence diagnosis.,
Introduction: Various PET tracers have been proposed for detection of recurrent disease in medullary thyroid carcinoma (MTC). No data have been reported comparing 18F-DOPA and 68Ga-somatostin analogues (SA) in MTC.
Conference: 8th Annual ENETSConcerence (2011)
Presenting Author:
Authors: Treglia G, Castaldi P, Villani M, Filice A, Ambrosini V,
Keywords: positron emission tomography, PET/CT, medullary thyroid carcinoma, neuroendocrine tumors,