Abstract Library

#4540 Retrospective analysis of somatostatin receptors expression in cohort of thoracic neuroendocrine neoplasms with immunohistochemistry method or PET/CT Ga68 DOTA-TATE

Introduction: Somatostatin receptors (SSTRs) expression in cohort of thoracic neuroendocrine neoplasms (NENs) is still not fully described. We attempted to evaluate the SSTR expression by IHC and PET/CT with Ga68 DOTA-TATE, as well as the sensitivity of both methods.

Conference:

Presenting Author: Evdokimova E

Authors: Evdokimova E, Vorobeva M, Zhulikov Y, Markovich A, Gorbunova V,

Keywords: NEN, thoracic, SSTR, IHC, DOTATATE, lung, thymus, mediastinum, LCNC, NET,

#3730 Somatostatin receptor expression in lung neuroendocrine tumors – An analysis of Dotatate PET scans

Introduction: Somatostatin receptor (SSTR) expression in metastatic lung neuroendocrine (carcinoid) tumors has not been well-characterized using modern positron emission tomography (PET) imaging. Understanding the degree and uniformity of SSTR expression is important to establish the role of SSTR-targeted treatments, including peptide receptor radiotherapy (PRRT), in lung NETs.

Conference:

Presenting Author: Al-Toubah T

Authors: Al-Toubah T, Montilla-Soler J, El-Haddad G, Strosberg J,

Keywords: PET dotatate, cu64, ga68, lung NET, SSTR Positive,

#3376 Usefulness of corrected SUV max change in metastatic NET lesions (before and after PRRT) obtained by [68Ga]Ga-DOTA-TATE PET/CT as a prognostic factor

Introduction: Peptide receptor radionuclide therapy (PRRT) is an effective therapeutic option for metastatic neuroendocrine tumor (NET)therapy. The high heterogeneity of the somatostatin receptors (SSTR) density in different NET metastatic lesions and inside single tumors probably influence an clinical outcome. Some studies suggest the response to PRRT assessed on the basis of imaging of SSTR may have a predictive value.

Conference:

Presenting Author:

Authors: Opalinska M, Sowa-Staszczak A, Kania-Kuc A, Al Maraih I, Hubalewska-Dydejczyk A,

Keywords: PRRT, NET, outcome, 68Ga-DOTATATE PET/CT, SSTR expression,

#3329 The role of 68Ga-DOTATATE PET/CT in extensive IgG4-positive fibrosis surrounding a mesenteric lymph node metastasis of a neuroendocrine tumor: A case report

Introduction: IgG4 expression is commonly seen in mesenteric tumor deposits from small intestine neuroendocrine tumors leading to a dense fibrotic response which can simulate IgG4-related sclerosing mesenteritis in medical images, hereby impeding a correct diagnosis.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Ahmadi Bidakhvidi N, Cuyle P, Sagaert X, Ballaux F, De Bruecker Y,

Keywords: small intestine neuroendocrine tumor, 68Ga-DOTATATE PET/CT, mesenterial lymph node, fibrosis, IgG4,

#3289 Short-interval, low-dose (SILD) Lu-177 DOTAiTATE therapy to overcome resistance to immunotherapy with PD-1 checkpoint inhibitors: Proof of concept to induce remission in patients with metastatic Merkel cell carcinoma and melanoma

Introduction: Immunotherapy with PD-1 immune checkpoint inhibitors (ICI) in Merkel cell carcinoma (MCC) or melanoma have proven efficacy.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Prasad V

Authors: Aicher A, Sindrilaru A, Beer A, Prasad V,

Keywords: PRRT, SILD, ICI, Merkel cell carcinoma, melanoma, tumor microenvironment remodelling,