Abstract Library

#2739 Epigenetic Landscape of Pancreatic Neuro-Endocrine Tumors Reveals Distinct Cells of Origin and Means of Tumor Progression

Introduction: Pancreatic Neuroendocrine Tumors (PanNETs) arise from cells of the Islets of Langerhans. The majority of PanNETs are non-functional and their cell of origin cannot be defined analysing specific hormone production. Cell of origin assessment has proven importance to identify risk factors, prevent tumour development, and tailor treatment in many malignancies. Recent data on super-enhancer signatures has suggested a potential origin of PanNET from α- or β-cells. We and others have shown that distinct epigenetic profiles assessed by DNA methylation (DNAme) characterize genomic and prognostic groups of PanNET.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Di Domenico A

Authors: Di Domenico A, Pipinikas C, Maire R, Bräutigam K, Vassella E,

Keywords: cell of origin, alpha, beta, methylation, expression, epigenetic, neuroendocrine, progression, PanNET, tumor,

#1889 FNA Under Percutaneous Ultrasound or Endoscopic Ultrasound for Pre-Operative Diagnosis and Grading Determination in PanNET. Are They Reliable to Define a Tailored Therapy?

Introduction: Fine-needle aspiration cytology (FNA)under percutaneous ultrasound guided (pUS)or endoscopic ultrasound(EUS)control is a minimally invasive technique allowing diagnosis and grading determination in pancreatic neuroendocrine tumors (PanNET).Obtaining a correct cytological diagnosis is crucial for a tailored therapy

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Rota R, Nessi C, Malpaga A, Impellizzeri H, Manfrin E,

Keywords: FNA, Ki67,

#1885 Web-Based Tailored Information and Support for Patients with a Neuroendocrine Tumor

Introduction: Patients with a neuroendocrine tumour (NET) frequently experience physical and psychosocial complaints. Novel strategies to provide information to optimize supportive care in these patients are of interest.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: de Hosson L

Authors: De Hosson L, Bouma G, Van Essen H, De Bock G, De Groot D,

Keywords: neuroendocrine tumor, information, quality,

#1835 A Prospective Service Evaluation of Systematic Gastroenterological Assessment and Management on Patients with Neuroendocrine Tumours in South East Wales

Introduction: Patients with NETs can experience gastrointestinal(GI) symptoms including diarrhoea, steatorrhoea and urgency.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Donnelly L, Tailor S, Reid K, Williams M, Lewis J,

Keywords: Quality of life, Diarrhea,

#1556 Staging in Small Bowel Neuroendocrine Tumours: Roles and Shortcomings

Introduction: Small bowel neuroendocrine tumours (SB NETs) frequently present with lymph node and/or distant metastases

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Malczewska A

Authors: Clift A, Faiz O, Al-Nahhas A, Bockisch A, Liedke M,

Keywords: neuroendocrine, tumour, staging,