Abstract Library

#3278 Simultaneously diagnosis of neuroendocrine neoplasm of unknown primary and breast cancer

Introduction: NeuroEndocrine Neoplasms (NENs) are considered rare neoplasms and can be developed in all organs.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Tsoukalas N

Authors: Tsoukalas N, Binas I, Kyriakopoulos G, Tassi V, Theodoroulea K,

Keywords: neuroendocrine neoplasm, intestinal, gastric, unknown primary, somatostatin analogues,

#2215 Development of Multiplex Biomarker Assay to Subtype Pancreatic Neuroendocrine Tumors (PanNETs) with Distinct Prognosis and Mutations

Introduction: Overall 5-year survival for PanNETs ranges from 25-100%. The treatment paradigm for PanNETs largely based upon grades, which is significantly heterogeneous. We previously defined three molecular subtypes (distributed grades) of PanNETs using PanNETassigner signature. There is an unmet clinical need for prognostic and predictive biomarkers and clinically-relevant assays to complement grade and improve patient stratification.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Sadanandam A

Authors: Sadanandam A, Young K, Nyamundanda G, Ragulan C, Lawlor R,

Keywords: molecular subtypes, biomarker assay, clinical assay, patient prognosis, subtype-specific mutations, NanoString Technologies, low-cost assay, pancreatic neuroendocrine tumors, grades, PanNETassigner subtype, patient stratification, pnet,

#1572 Study of the Biological Significance of the IGF-IEc (MGF) in Well and Poorly Differentiated Neuroendocrine Neoplasms

Introduction: Insulin-like growth factor-I (IGF-I) has a key role in cell proliferation, differentiation, migration, and survival. Different IGF-I mRNA transcripts, such as IGF-IEc (mechano growth factor, MGF), are produced by alternative splicing. MGF has been implicated in muscle regeneration process as well as in the pathophysiology of various types of cancer.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Alexandraki K

Authors: Alexandraki K, Philippou A, Boutzios G, Theohari I, Moschouris P,

Keywords: Neuroendocrine neoplasms, MGF, IGF-IEc, ki-67,

#933 The Cytotoxic Effect of Sunitinib on Human Bronchial Carcinoid Cell Lines and Primary Cultures is Counteracted by EGF and IGF-1, but not by VEGF

Introduction: Bronchial carcinoids (BC) are rare tumors originating from endocrine cells dispersed in the respiratory epithelium. The main BC treatment is surgery, but which is not feasible for large, infiltrating and metastatic disease. In these settings, medical therapy is often tried. Therefore it is important to identify new therapeutic targets and new molecules capable of providing adequate medical treatment for patients with BC. Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase inhibitor.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Gagliano T, Gennari G, Tassinari M, Bellio M, Molè D,

Keywords: BC, RTK, Sunitinib,