Abstract Library

#4240 Plasma extracellular vesicles number and size distinguish patients with neuroendocrine neoplasms

Introduction: Neuroendocrine Neoplasms (NENs) are heterogeneous neoplasms, whose metastatic potential is challenging to predict. Extracellular vesicles (EVs) have been described as mediators of communication between the tumor cells and their microenvironment, driving the formation of metastatic niches.

Conference:

Presenting Author: Angelioudaki I

Authors: Angelioudaki I, Pantazatou V, Tzingounis A, Kataki A, Memos N,

Keywords: Extracellular vesicles, plasma, Gastroenteropancreatic NEN,

#4209 Transcriptomic and spliceosomic landscapes of pancreatic neuroendocrine tumors generated through Oxford Nanopore Technology sequencing

Introduction: Pancreatic Neuroendocrine tumors (PanNETs) are rare neoplasms with heterogenous nature, still poorly understood. Their low mutational burden has prompted to explore other molecular aspects, from epigenomics to transcriptomics. Increasing evidence indicates that transcriptomic changes, often derived from alterations in alternative splicing, can generate isoforms with oncogenic potential. In this context, long-read Oxford Nanopore Technology (ONT) has emerged as an ideal suited sequencing tool to deeply study transcriptomics and splicing variants.

Conference:

Presenting Author: Moreno Montilla M

Authors: Moreno Montilla M, Jones G, Jeffries A, Blazquez Encinas Rey R, Bamford R,

Keywords: Pancreatic Neuroendocrine Tumor, Oxford Nanopore Technology Sequencing, Transcriptomics, Splicing, Fusion Genes,

#4076 Machine learning model: Predicting prognosis in neuroendocrine tumors

Introduction: Neuroendocrine tumors (NETs) have a heterogeneous clinical course. Even with similar Ki-67 proliferative index/morphology, the course varies in patients with similar pathological characterization.

Conference:

Presenting Author:

Authors: Varghese D, Naimian A, Yazdian P, Lokre O, Perk T,

Keywords: Neuroendocrine tumor, artificial intelligence, DOTATATE scan,

#4074 Clinical, genetic and histopathological characterisation of patients with multiple endocrine neoplasia type 1 in two high complexity hospitals in Medellín, Colombia

Introduction: Limited observational data exist regarding the characterization of patients with Multiple Endocrine Neoplasia Type 1 (MEN-1) in Latin America, particularly in Colombia. This scarcity has led to a reliance on studies that may not precisely depict the actual behaviour of the disease within the population.

Conference:

Presenting Author:

Authors: Roman-Gonzalez A, Gil-Gonzalez M, Pérez-Giraldo E, Agredo Delgado V, Lopez-Montoya V,

Keywords: multiple endocrine neoplasia type 1, neuroendocrine tumor, acromegaly, cushing disease, hyperparathyroidism,

#3961 Enhancer heterogeneity of lung carcinoids reveals sensitivity to FGF signaling inhibition

Introduction: Well-differentiated low grade lung carcinoids are histo-pathologically classified as typical and atypical, but each subtype is still heterogenous both at the molecular level and its clinical manifestation. Therefore, the treatment of these patients is challenging. The two main challenges are the lack of effective drug treatments and the lack of reliable biomarkers to guide management since the disease in patients with the same tumor grade/stage often has different clinical courses. The genetic, epigenetic, and developmental programs that drive lung carcinoids remain obscure, limiting our abilities to suggest new biomarkers and drug targets.

Conference:

Presenting Author: Drier Y

Authors: Davis E, Avniel-Polak S, Hecht M, Grozinsky-Glasberg S, Drier Y,

Keywords: FGF Signaling, Lung carcinoids, Enhancers,