Abstract Library

#4139 Characterisation of new biomarkers from patients with neuroendocrine cancer using liquid biopsy methods

Introduction: Neuroendocrine tumors originate from neuroendocrine cells. Clinicians diagnose and track these tumors not only but also by analysing patients' blood for biomarkers. Including liquid biopsy in early detection and monitoring can improve patient outcomes.

Conference:

Presenting Author:

Authors: Pachnikova G, Jann H, Tacke F, Keilholz U,

Keywords: liquid biopsy, circulating tumor cells, cell-free DNA, neuroendocrine tumor, case study, copy number variations,

#4056 High expression of ADAM15 in non-functional pancreatic neuroendocrine tumors is associated with high-density tumor-infiltrating neutrophils and predicts poor outcome

Introduction: Non-functional pancreatic neuroendocrine tumors (NF-PanNETs) displayed heterogeneous prognoses. Copy number variations (CNVs) of ADAM15 significantly increased in patients who underwent postoperative early recurrence. ADAM15 (a disintegrin and metalloproteinase 15) has been identified as a key molecule in progression and metastasis of many tumors, regulating immune infiltration. However, correlation between ADAM15 and NF-PanNETs remains unknown.

Conference:

Presenting Author:

Authors: Tang L, Ying Y, Peng M, Wang Y, Lou W,

Keywords: pancreatic neuroendocrine tumor, recurrence, metastasis, ADAM15, tumor-infiltrating neutrophils,

#3392 The chromosome 18 loss of heterozygosity axis of small intestinal neuroendocrine tumors

Introduction: Small intestinal neuroendocrine tumors (siNETs) are rare neoplasms which have low mutational burdens: With subtypes characterised in terms of copy number variation (CNV). Subtypes are defined as: Chromosome 18 loss of heterozygosity (18LOH), multiple copy number variation (MultiCNV), or no copy number variations (NoCNV). 18LOH tumors are associated with improved outcomes, the reasons for which are poorly understood.

Conference:

Presenting Author: Waterfield S

Authors: Waterfield S, Yousefi P, Amaulu A, Relton C, Thirlwell C,

Keywords: neuroendocrine, small intestinal, methylation, epigenetics, omics,

#1523 Multiregion Analysis Reveal Evolutionary Patterns and a Chromosomal Instability Signature in Pancreatic Neuroendocrine Tumours

Introduction: Pancreatic neuroendocrine tumors (PNETs) are potentially lethal diseases that show variable degrees of proliferation and invasiveness. Although genetic subgroups have been suggested to give prognostic information the impact of clonal evolution to the development and outcome of PNETs remains unexplored.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Crona J

Authors: Crona J, Backman S, Kugelberg J, Maharjan R, Björklund P,

Keywords: Cancer evolution, Molecular genetics, Neuroendocrine Tumor,