Abstract Library

#2988 Epigenetic Treatment with Histone Deacetylase Inhibitor Enhances Uptake of [111In]In-DOTA-TATE by Increased SST2 Expression on Neuroendocrine Tumor Cells

Introduction: The somatostatin-2 receptor (SST2) is a target for peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumors (NETs). By using epigenetic drugs, which can regulate gene transcription, PRRT efficacy may be further improved due to enhanced SST2 expression.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Klomp I

Authors: Klomp I, Dalm S, van Koetsveld P, Dogan-Oruç F, de Jong M,

Keywords: neuroendocrine tumors, bon-1, epigenetic, histone, histone deacetylase inhibitor, HDACi, upregulation, reversibility, somatostatin receptor-2, somatostatin,

#912 Serial 89Zr-bevacizumab PET in Patients with Neuroendocrine Tumors before and on Everolimus Treatment

Introduction: Everolimus increases PFS in patients with advanced NETs. Currently, no biomarkers are available for early selection of patients who will benefit from everolimus. Everolimus can reduce VEGF-A production by tumor cells.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Brouwers A, Van Asselt S, Oosting S, De Jong J, Lub-de Hooge M,

Keywords: neuroendocrine tumors, 89Zr-bevacizumab PET, VEGF-A, everolimus, biomarker,

#618 Angiogenic Characteristics of Radiological Hypervascular Liver Tumors (NET, Hepatocellular Carcinoma) and Hypovascular Colorectal Liver Metastases and Their Microenvironment.

Introduction: Tumor and microenvironment are important for tumor progression. Liver tumors can be hypervascular or hypovascular during the arterial phase of cross-sectional imaging.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: de Jong K

Authors: Van der Wal G, Gouw A, Moorlag H, Bulthuis M, Molema G,

Keywords: angiogenesis, VEGF, Angiopoietin, CT imaging,

#16 Endoglin as indicator of metastatic neuroendocrine tumors of the pancreas

Introduction: Neuroendocrine tumors of the pancreas are rare, highly vascularized tumors. Endoglin, a Transforming Growth Factor-β co-receptor, is a marker for angiogenic endothelial cells. Angiogenesis is required for tumor progression and the development of metastases. Recently, endoglin expression was found to be a prognostic marker in pancreatic carcinomas. However, the role of endoglin in neuroendocrine pancreatic tumors has so far not been studied.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Kuiper P, Verspaget H, de Jonge-Muller E, Hawinkels L, Biemond I,

Keywords: endoglin, pancreatic neuroendocrine tumor, angiogenesis, metastases,