Abstract Library

#3961 Enhancer heterogeneity of lung carcinoids reveals sensitivity to FGF signaling inhibition

Introduction: Well-differentiated low grade lung carcinoids are histo-pathologically classified as typical and atypical, but each subtype is still heterogenous both at the molecular level and its clinical manifestation. Therefore, the treatment of these patients is challenging. The two main challenges are the lack of effective drug treatments and the lack of reliable biomarkers to guide management since the disease in patients with the same tumor grade/stage often has different clinical courses. The genetic, epigenetic, and developmental programs that drive lung carcinoids remain obscure, limiting our abilities to suggest new biomarkers and drug targets.

Conference:

Presenting Author: Drier Y

Authors: Davis E, Avniel-Polak S, Hecht M, Grozinsky-Glasberg S, Drier Y,

Keywords: FGF Signaling, Lung carcinoids, Enhancers,

#3760 Comprehensive genomic and transcriptomic analysis of lung carcinoid reveals molecular differences between typical carcinoid and atypical carcinoid

Introduction: Typical carcinoids (TCs) and atypical carcinoids (ACs) are two histotypes of lung carcinoids (LCs) exhibiting different prognoses. However, the diagnosis can be difficult for small biopsies. Moreover, the differences in molecular characteristics of the two subtypes lack understanding.

Conference:

Presenting Author: Guo Y

Authors: Guo Y, Tian C, Cheng Z, Hu S, Chen Q,

Keywords: lung carcinoid, histological subtypes, genomic alteration, transcriptomic difference, drug targets,

#1001 Forkheadbox Proteins as Novel Drug Targets in Gastroenteropancreatic Neuroendocrine Tumor Disease: Inhibition of FoxM1 Exerts Antiproliferative Effects in GEP-NEN Cell Lines

Introduction: Forkheadbox proteins (Fox proteins) are transcriptions factors. They are highly conserved key players in a large number of cellular processes. Fox proteins have been described as acting as both tumor suppressors and oncogenes. Most notably, they operate in the context of the majority of cancer-related pathways. Information about the fuunction of these proteins in gastroenteropancreatic neuroendocrine neoplasias is scant.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Briest F

Authors: Briest F, Freitag H, Lewens F, Kaemmerer D, Hörsch D,

Keywords: Forkheadbox proteins, signalling network, immunohistochemistry, siRNA, microarray technique,

#529 Alternative Splicing and Differential Gene Expression in Pancreatic NETs

Introduction: Protein isoforms resulting from differentially spliced mRNA may constitute peculiar drug targets or markers for cancer diagnosis. We here present a new DNA array that allows identification of splice variation and differential expression for 357 G protein-coupled receptors (GPCR) and 11 proteins of the extracellular matrix.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Körner J, Schäfer C, Schulz P, Wiedenmann B, Grötzinger C,

Keywords: pNET,