Abstract Library

#2745 Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids

Introduction: Lung carcinoids (LCs) are rare and slow growing primary lung neuroendocrine tumors. The WHO classify LCs into atypical and typical carcinoids. Recent studies have shown that the reproducibility of LCs classification and its prognostic efficacy have high interobserver variability

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Laddha S

Authors: Laddha S, da Silva E, Robzyk K, Untch B, Ke H,

Keywords: MEN1, Lung Carcinoid, Lung Cancer, ASCL1, Novel Molecular Subtypes, Genotype to Phenotype, Integrative Genomic Analysis, Biomarkers, Genomics and Epigenomics,

#2155 Menstrual Dysfunction in Women with Prolactinomas

Introduction: Hyperprolactinemia syndrome (HPS) is a set of symptoms with typical increase in serum prolactin accompanied by galactorrhea, hypogonadism and potential infertility

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Safarova M, Khalimova Z, Axmedova S, Issaeva S, Gumarova A,

Keywords: prolactinoma, hyperprolactinemia, dopamine agonists,

#2130 Remote Tracking of Symptoms, QoL and Wellbeing within the New Wales NET Service

Introduction: Patients with NETs have worse health-related quality of life (HRQoL) than the general population. Technological advances have significantly increased electronic patient-reported outcome (ePRO) data collection capabilities. There is little longitudinal PRO/ePRO data and limited data on gastrointestinal symptoms, particularly ‘diarrhoea’, in NET patients.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Reynolds M

Authors: Reynolds M, Tucker L, Ankita B, Powell C, Hopps R,

Keywords: Quality of Life, Symptoms, ePRO, Diarrhoea, NET service, Longitudinal Data, CABARET, app,

#2129 Phosphohistone H3 (PHH3) Immunohistochemical Staining Outperforms Conventional H&E Mitotic Count in Classifying Pulmonary Carcinoids

Introduction: Pulmonary carcinoids (PC) are well-differentiated NETs and are classified as typical carcinoid (TC) and atypical carcinoid (AC). Despite the fact that TC and AC exhibit significant differences in patient survival, their classification depends on relatively subtle differences in mitotic count (MC). Although careful counting of mitotic figures (MF) is essential, it is a very subjective task, time-consuming and lacks of sensitivity and interobserver reproducibility, due to selection bias of the hot spots, heterogeneous distribution of MF, difficulty in distinguishing MF from similar chromatin changes (i.e. in apoptotic cells or due to crush, karyorrhectic debris, pyknosis or apoptosis).

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Luong T

Authors: Luong T, McCaughran W, Caplin M, Toumpanakis C, Thirlwell C,

Keywords: Phosphohistone H3, Pulmonary Carcinoids, Typical Carcinoid, Atypical Carcinoid, Mitotic Count, H&E,

#2051 Do We Need Hormonal Therapy for Pancreatic Neuroendocrine Tumors? An Effort to Reduce the Size of PanNETs

Introduction: Pancreatic neuroendocrine tumors although rare , have been significantly increased over the past few decades. They range from indolent to highly aggressive in nature. Just like breast and endometrial carcinoma are hormonal dependant,

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Fatima A

Authors: Fatima A, Zaidi S,

Keywords: high positive ERβ, Hormonal therapy, small size PanNET,