Abstract Library

#191 Immunohistochemical Analysis of Epithelial-Mesenchymal Transition Markers in Neuroendocrine Tumors of the Lung

Introduction: The increased motility and invasiveness of cancer cells in the first phase of metastasis are reminiscent of epithelial–mesenchymal transition (EMT) during embryonic development.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Galván J, González M, Fonseca P, Folgueras M, Astudillo A,

Keywords: EMT, snail, slug, twist, foxC2, cadherin, pulmonary neuroendocrine tumors ,

#41 Immunohisochemical evaluation of EMT regulators, E- and N-cadherin in neuroendocrine Tumors of the Gastro-Entero-Pancreativ system

Introduction: Local tumor invasion represents the first step of the metastatic cascade of carcinomas, and requires changes in cell adhesion and migration properties of tumor cells. This biologic process is known as epithelial-mesenchymal transition (EMT). One key biochemical change associated with EMT is the loss of E-cadherin expression promoted by specific transcriptional repressors such as Snail, Slug, and Twist. Overexpression of EMT inducers increases other factors, such as FoxC2, although its role in EMT is poorly understood. Neuroendocrine tumors (NETs) of the gastroenteropancreatic (GEP) system, originated from the diffuse endocrine system, represent a heterogeneous group of tumors. Their prevalence has increased substantially over the past three decades, without substantial improvements in their clinical management, and their variable clinical course cannot be predicted by common clinicopathological parameters. Thus, new prognostic markers are urgently needed.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: GALVÁN J, GONZÁLEZ-MEANA M, FOLGUERAS M, ASTUDILLO A,

Keywords: gastroenteropancreatic neuroendocrine tumors, Twist, FoxC2, N-cadherin, E-cadherin, EMT,