Abstract Library

#191 Immunohistochemical Analysis of Epithelial-Mesenchymal Transition Markers in Neuroendocrine Tumors of the Lung

Introduction: The increased motility and invasiveness of cancer cells in the first phase of metastasis are reminiscent of epithelial–mesenchymal transition (EMT) during embryonic development.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Galván J, González M, Fonseca P, Folgueras M, Astudillo A,

Keywords: EMT, snail, slug, twist, foxC2, cadherin, pulmonary neuroendocrine tumors ,

#110 Slug represents an important regulator of E-cadherin expression in neuroendocrine tumor cells of the pancreas

Introduction: Neuroendocrine tumors of the pancreas form an inhomogenous group of epithelial neoplasms. They differ from other types of pancreatic cancers by showing an extended survival of patients, which is due to a mostly slow proliferation rate of the tumor. However, some of these neuroendocrine tumors are characterized by an early onset of metastases, which cannot be predicted by any available method. The epithelial to mesenchymal transition (EMT) represents a central part of cell migration and metastasis. During EMT, cells loosen their cellular contacts, leave the tissue, and become migrating single cells. One of the integral compounds of cell adhesion represents the E-cadherin adhesion module, which contains mostly E-cadherin and several catenins. A loss of this adhesion module is associated with tumor progression, migration and metastasis in many types of cancer.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: König A

Authors: König A, Reutlinger K, Ellenrieder V, Gress T, Fendrich V,

Keywords: neuroendocrine tumor of the pancreas, E-cadherin, Slug, cell adhesion,

#41 Immunohisochemical evaluation of EMT regulators, E- and N-cadherin in neuroendocrine Tumors of the Gastro-Entero-Pancreativ system

Introduction: Local tumor invasion represents the first step of the metastatic cascade of carcinomas, and requires changes in cell adhesion and migration properties of tumor cells. This biologic process is known as epithelial-mesenchymal transition (EMT). One key biochemical change associated with EMT is the loss of E-cadherin expression promoted by specific transcriptional repressors such as Snail, Slug, and Twist. Overexpression of EMT inducers increases other factors, such as FoxC2, although its role in EMT is poorly understood. Neuroendocrine tumors (NETs) of the gastroenteropancreatic (GEP) system, originated from the diffuse endocrine system, represent a heterogeneous group of tumors. Their prevalence has increased substantially over the past three decades, without substantial improvements in their clinical management, and their variable clinical course cannot be predicted by common clinicopathological parameters. Thus, new prognostic markers are urgently needed.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: GALVÁN J, GONZÁLEZ-MEANA M, FOLGUERAS M, ASTUDILLO A,

Keywords: gastroenteropancreatic neuroendocrine tumors, Twist, FoxC2, N-cadherin, E-cadherin, EMT,