Abstract Library

#343 PCR Assessment of Carcinoid Lymph Node Metastasis CgA Transcript Outperforms Immunostaining, Tyramide Signal Amplification and H&E and Significantly Upstages Disease

Introduction: Accurate neuroendocrine tumor (NETs) staging is vital for determining therapeutic strategy. Sensitive techniques to facilitate identification of metastases (mets) are of critical clinical relevance.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Lawrence B, Kenney B, Kidd M, Modlin I,

Keywords: CgA, immunofluorescence, histopathology, lymph node, neuroendocrine tumor, PCR, tyramide, up-staging,

#69 Frequent biological association of Merkel cell polyomavirus with Merkel cell carcinomas

Introduction: Merkel cell polyomavirus (MCPyV) DNA has been detected by PCR in 75–100% of Merkel cell carcinomas (MCC), an aggressive neuroendocrine skin cancer. MCPyV is a 5.4 kb DNA virus that expresses tumor (T) antigen in tumor tissues.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Speel E

Authors: Speel E, Schmidt A, Baumann M, Haesevoets A, Diebold J,

Keywords: Merkel cell polyoma virus, Merkel cell carcinoma, neuroendocrine skin cancer, FISH, large T antigen,