Abstract Library

#3381 Time to reclassify gastric carcinomas of diffuse type to neuroendocrine carcinomas

Introduction: The difference between adeno- and neuroendocrine carcinomas has been disputed for decades. Occurrence of neuroendocrine tumor cells in adenocarcinomas has been recognized, but the distinction between them has been made upon a certain number of tumor cells with a neuroendocrine marker. The number of positive cells depends upon the sensitivity of the method. Carcinogenesis generally results in loss and not gain of function. New gene expression of markers specific for a cell type seldom occurs.

Conference:

Presenting Author: Waldum H

Authors: Waldum H, Mjønes P,

Keywords: adenocarcinoma, neuroendocrine carcinoma, neuroendocrine tumor (NET), classification,

#343 PCR Assessment of Carcinoid Lymph Node Metastasis CgA Transcript Outperforms Immunostaining, Tyramide Signal Amplification and H&E and Significantly Upstages Disease

Introduction: Accurate neuroendocrine tumor (NETs) staging is vital for determining therapeutic strategy. Sensitive techniques to facilitate identification of metastases (mets) are of critical clinical relevance.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Lawrence B, Kenney B, Kidd M, Modlin I,

Keywords: CgA, immunofluorescence, histopathology, lymph node, neuroendocrine tumor, PCR, tyramide, up-staging,

#69 Frequent biological association of Merkel cell polyomavirus with Merkel cell carcinomas

Introduction: Merkel cell polyomavirus (MCPyV) DNA has been detected by PCR in 75–100% of Merkel cell carcinomas (MCC), an aggressive neuroendocrine skin cancer. MCPyV is a 5.4 kb DNA virus that expresses tumor (T) antigen in tumor tissues.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Speel E

Authors: Speel E, Schmidt A, Baumann M, Haesevoets A, Diebold J,

Keywords: Merkel cell polyoma virus, Merkel cell carcinoma, neuroendocrine skin cancer, FISH, large T antigen,