5-Fluorouracile Plus Dacarbazine in Metastatic Digestive Neuroendoendocrine Tumors: Efficacy and Potential Biomarkers

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Introduction: The 5-fluorouracile (5FU) + dacarbazine (DTIC) combination has been poorly evaluated in NET

Aim(s): To assess the efficacy and safety of 5FU-DTIC and to explore potential predictive factors of efficacy

Materials and methods: Medical and imaging records of all consecutive patients (pts) with metastatic well-differentiated pancreatic (p) or small intestine (si) NET receiving 5FU-DTIC between 2004 and 2015 in 3 expert centres were retrospectively reviewed. Tumor expression of DAXX, ATRX, MGMT and APNG was centrally performed

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: de Mestier L

Authors: De Mestier L, Cros J, Hentic O, Legoux J, Muller N,

Keywords: chemotherapy, tumor response, tolerance, pfs,