Abstract Library
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Participants of the ENETS Conference in 2024 can now access the abstract booklet, e-posters and videos, slide decks of talks, the poster carousel, and more via My ENETS.
ENETS Abstract Search
Introduction: Temozolomide (TMZ) and dacarbazine (DTIC) are alkylating agents (ALK) with antitumor efficacy in metastatic PanNET. Rechallenging ALK following prior efficacy is commonly performed but has not been evaluated.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: De Rycke O, Walter T, Perrier M, Hentic O, Lombard-Bohas C,
Keywords: alkylating agents, pancreatic NET, re-challenge, chemotherapy,
Introduction: Neuroendocrine tumours of the gastrointestinal tract cause carcinoid syndrome and carcinoid heart disease. These tumours secrete serotonin, which can bind to heart valves and cause fibrosis and valve incompetence. Most cases involve the tricuspid valve +/- pulmonary valve. Medical management comprises diuretics for fluid overload and somatostatin analogues to reduce circulating serotonin. Definitive treatment is heart-valve replacement surgery which improves exercise tolerance but has high perioperative mortality. We have previously reported that valve-replacement surgery can reduce 5-hydroxyindoleacetic acid (5-HIAA) levels, reflecting a decline in hormone activity.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Shah H
Authors: Shah H, Sagar V, Venkataraman H, Steeds R, Rooney S,
Keywords: carcinoid, carcinoid syndrome, neuroendocrine tumour, carcinoid heart disease, 5hiaa,
Introduction: Preclinical studies have suggested that metformin has antitumor effects, likely due to blockage of mTOR pathway through AMPK and decreased insulin levels. A retrospective study showed that metformin combined with everolimus to treat related hyperglycemia offered longer progression-free survival (PFS) in patients (pts) with pancreatic neuroendocrine tumors (NET).
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Glasberg J
Authors: Glasberg J, Talans A, Lopez R, Recchimuzzi D, Riechelmann R,
Keywords: neuroendocrine tumors, metformin, clinical trial,
#2737 Identification of a Novel MAFA Missense Mutation Causing Familial Insulinomatosis
Introduction: Insulinomatosis is a rare pancreatic disease characterized by an adult-onset condition of recurrent hyperinsulinemic hypoglycemia caused by multiple insulin-secreting neuroendocrine tumors.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Fottner C
Authors: Fottner C, Sollfrank S, Ghiasi M, Ferrata M, Schad A,
Keywords: Insulinomatosis, Insulinoma, hyperinsulinemic hypoglycemia, MAFA,
Introduction: We have shown immunohistochemistry (IHC) expression of estrogen (ER) and progesterone receptors (PR) in 20.8% and 18.8% of 96 NET patients (pts). An old clinical trial (Mortel C, 1984) suggested antitumor effects of estrogen/progesterone-directed therapies in NET. Yet the effects of an antiestrogen agent in NET pts whose tumor express ER and/or PR are unknown.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Riechelmann R
Authors: Riechelmann R, Donadio M, Felismino T, Fonseca de Jesus V, Mello C,
Keywords: neuroendocrine, estrogen, progesterone, clinical trial,