Finding the Ways to Determine the Prognosis of Pulmonary Carcinoids with Certain Genes/Markers in Pakistan

#2050

Introduction: Pulmonary neuroendocrine tumors are classified into four subtypes from well differentiated to poorly differentiated high grade large cell neuroendocrine carcinomas. Because of the difficult histological classification and a cancer free period following surgery, it is often difficult to predict certain prognostic factors.

Aim(s): We aim to analyse the prognostic factors of pulmonary carcinoids. In our study we also aim to find the the patterns of CD44, OTP and RET.

Materials and methods: The study was conducted in tertiary care. CD44, OTP and RET were analysed in 70 frozen carcinoids by using PCR. mRNA expression of these genes were assessed. Methylation and mutation analysis was used to assess RET proto oncogene. Immmunohistochemistry for CD44 and protein expression for OTP was conducted.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Fatima A

Authors: Fatima A, Zaidi S,

Keywords: prognostic markers, CD44, OTP, genes regulation, cancer prognosis,