Multivisceral Transplantation and Vascularised Sentinel Forearm Flap for a Metastatic Gut-Derived Neuroendocrine Tumour: Follow-up


Introduction: We previously reported the first documented case of a novel approach in a patient with extensive mesenteric metastases from a small bowel (SB) NET: this combined multivisceral transplantation (MVT) and a vascularised sentinel forearm flap (VSFF) from the same donor.

Aim(s): We re-present this case after prolonged follow-up.

Materials and methods: A male patient was diagnosed with a well-differentiated Grade 1 (Ki67 <1%) NET when aged 44. Initial biochemistry was: chromogranin A 395pmol/L (normal <60), chromogranin B 349pmol/L (normal <150), 24hr urinary 5-HIAA 643 ┬Ámol/L (normal <40). Pre-operative 68-Ga DOTATATE PET/CT demonstrated uptake in an aorto-caval lymph node and bulky mesenteric disease, which was confirmed at laparotomy as stage IV disease encasing the mesenteric root. Numerous lymph nodes and multifocal primary tumour (7 sub-centimetre lesions) were also found at surgery.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Malczewska A

Authors: Clift A, Giele H, Vrakas G, Reddy S, Macedo R,

Keywords: neuroendocrine, transplantation, multivisceral, forearm flap,

To read the full abstract, please log into your ENETS Member account.