Pancreatic Neuroendocrine Neoplasms: Dissecting the Molecular Heterogeneity

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Introduction: Pancreatic neuroendocrine neoplasms (PNENs) are a group of rare but biologically and clinically heterogeneous neoplasms with variable patient outcomes. Little is known about the molecular differences between PNENs and the biologic significance of such divergence.

Aim(s): Our study aims to uncover the molecular factors that underlie the clinical and biological heterogeneity among PNENs for a better understanding and potential classification of this disease.

Materials and methods: We applied next-generation sequencing to profile the exome and transcriptome, and quantitative mass-spectrometry to profile the global proteome of 41 primary PNEN specimens to identify DNA aberrations, and RNA and protein level differences.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Yang K, Kalloger S, Aird J, Lee M, Colborne S,

Keywords: Pancreatic neuroendocrine neoplasms, Exome, Transcriptome, Proteome,