Abstract Library

#3028 Pancreatic Neuroendocrine Neoplasms: Dissecting the Molecular Heterogeneity

Introduction: Pancreatic neuroendocrine neoplasms (PNENs) are a group of rare but biologically and clinically heterogeneous neoplasms with variable patient outcomes. Little is known about the molecular differences between PNENs and the biologic significance of such divergence.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Yang K, Kalloger S, Aird J, Lee M, Colborne S,

Keywords: Pancreatic neuroendocrine neoplasms, Exome, Transcriptome, Proteome,

#2108 Molecular Characterization of Primary and Metastatic Pancreatic Neuroendocrine Tumors

Introduction: Pancreatic neuroendocrine tumours (PNETs) are a heterogeneous group of rare pancreatic neoplasms often diagnosed with distant metastases, which are associated with significantly poorer prognosis. Recurrent somatic mutations, chromosomal aberrations and gene expression signatures in PNETs have been described, but the clinical significance of these molecular changes is still poorly understood, and the clinical outcomes of PNET patients remain highly variable.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Yang K, Wong H, Shen Y, Colborne S, Kalloger S,

Keywords: pancreatic neuroendocrine tumor, metastasis, primary tumor, proteomics, transcriptomics,

#1501 Inhibition of Intestinal Neuroendocrine Tumor by a New Marker of Normal Neuroendocrine Cells

Introduction: Although gastrointestinal neuroendocrine tumors are increasing worldwidely, few treatment options could be chosen

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Guo Y

Authors: Pan B, Yang W, Zhang T, Guo Y,

Keywords: GEP-NETs, Wnt, marker,

#773 Thymosin β4 as Putative Marker in Neuroendocrine Tumors

Introduction: Neuroendocrine tumors (NETS) arise from the diffuse endocrine system which produce biogenic amines and peptides that could be potential biomarker. We previously analysed proteomes secreted by NET cell lines and identified mac2BP as a putative marker which was also elevated in patients compared to healthy controls.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Mandair D, Marotta D, Ho J, Waugh M, Srirajaskanthan R,

Keywords: proteomics,

#357 Alternative Splicing and Differential Gene Expression in Pancreatic NETs

Introduction: Alternative splicing is an important mechanism to increase diversity of the proteome in higher organisms. These protein isoforms can provide as a selective drug target or marker for cancer diagnosis. We present here a new DNA array that allows identification of splice variation and differential expression of 357 G protein-coupled receptors (GPCR) and 11 proteins of the extracellular matrix.

Conference:

Presenting Author:

Authors: Körner J, Wiedenmann B, Grötzinger C,

Keywords: splice variants array,