Abstract Library

#4428 Tumour-derived apolipoprotein E drives temozolomide chemoresistance by reprogramming lipid metabolism and activating the homologous recombination repair pathway in pancreatic neuroendocrine tumours

Introduction: Temozolomide (TMZ) is a first-class clinical drug for patients with pancreatic neuroendocrine tumours (pNETs). However, the therapeutic effects of TMZ are limited because of the chemoresistance of pNET cells.

Conference:

Presenting Author: Ji S

Authors: Lou X, Ji S, Xu X, Chen J, Yu X,

Keywords: Temozolomide, pancreatic neuroendocrine tumour, chemoresistance,

#4084 Proteomic profiling reveals C1QA and COMP as promising plasma biomarkers for early detection of pancreatic neuroendocrine tumors

Introduction: PanNETs (pancreatic neuroendocrine tumors) have distinctive clinical features and may vary in aggressiveness. Current diagnostic methods, including biochemical tests and imaging techniques, lack the required sensitivity and specificity, with invasive and expensive procedures. The urgent need for specific, cost-effective biomarkers for early PanNET screening and diagnosis is emphasized, especially in developing countries.

Conference:

Presenting Author: Gorai P

Authors: Gorai P, Bharti P, Surabhi A, Kumar S, Rajacharya G,

Keywords: Pancreatic neuroendocrine tumor, Proteomics, Biomarker, Plasma,

#3793 Decellularised pancreas explants as a novel 3D model for pancreatic neuroendocrine tumors (PNETs) biomarker discovery

Introduction: The lack of preclinical models of pancreatic neuroendocrine tumors (pNETs) challenges advancement in biomarker discovery. Culturing cancer cells in their native tissue enables the study of complex tumor cell-ECM interactions, products of which could be utilised as disease biomarkers.

Conference:

Presenting Author: Ney A

Authors: Ney A, Al-Akkad W, Sedlak E, Garcia-Sampedro A, Hall A,

Keywords: Disease model, Tumor microenvironment, Biomarker discovery, Pancreatic NET,

#3450 Re-cellularised human pancreas 3D scaffolds as a novel disease model of pancreatic neuroendocrine tumors (pNETs)

Introduction: A lack of preclinical models of pNETs challenges understanding of complex interactions between cancer cells and their stroma. Traditional in vitro disease models such as 2D cultures however, induce phenotypic and functional drifts consequent of their removal from the native, tissue specific niche. Culturing pNET cells in their native tissue recapitulates specific cell-ECM interactions and tissue remodeling processes.

Conference:

Presenting Author: Ney A

Authors: Ney A, Sedlak E, Garcia-Sampedro A, Hall A, Bhamra A,

Keywords: Disease model, pancreatic neuroendocrine tumor, tissue remodeling, stroma, biomarker,

#3358 Evaluation of Helicobacter pylori proteins in the pathogenesis of type 1 gastric neuroendocrine tumor and urticaria. In-silico approach

Introduction: Helicobacter pylori (Hp) has been linked to several diseases such as chronic spontaneous urticaria (CSU), gastritis, and type 1 gastric neuroendocrine tumors (T1-GNET). Although these diseases seem to have different mechanisms, their relationship with Hp suggests a possible common inflammatory pathway.

Conference:

Presenting Author:

Authors: González Devia D, Sánchez Caraballo A, Guzman Ruiz Y, Sanchez Caraballo J, Múnera Gomez M,

Keywords: autoimmune gastritis, urticaria, in-silico analysis, type 1 gastric neuroendocrine tumor,