Predominant volumetric phenotype in dual PET and overall survival in NENs

#4340

Introduction: Dual 18F-FDG/68Ga-DOTATATE PET can predict NEN prognosis and guide treatment choice. However, research to date (such as the NEPTET score) has focused on the dual PET phenotype of single-point lesions rather than of the total disease volume.

Aim(s): To measure the predominant dual PET phenotype by volume in NEN patients and assess its prognostic relevance.

Materials and methods: We conducted a retrospective analysis on 152 GEPNEN patients undergoing dual 68Ga-DOTATATE/18F-FDG PET within 28 days of each other. Dual PET scans were contoured and confirmed by an experienced nuclear medicine physician. Disease volume was marked as C1 (DOTATATE avid, FDG non-avid), C2 (both DOTATATE and FDG avid) or C3 (FDG avid, DOTATATE non-avid). After computing these volumes, patients were classified by the predominant phenotype (i.e. the C-class with the highest volume). Overall and progression-free survival were compared using the log-rank test for these cohorts.

Conference:

Presenting Author: Chan D

Authors: Chan D, Bernard E, Mokhtar S, Chou A, Gill A,

Keywords: Prognostic biomarker, PET/CT, tumour volume, 18F-FDG, 68Ga-DOTATATE,