“Wait and Watch” Approach for Small Pancreatic Neuroendocrine Tumors (pNETs): Prognosis and Survival in 51 Consecutive Patients.

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Introduction: The most appropriate management for small non-functioning pancreatic neuroendocrine tumors (pNETs) is lacking and whether all these lesions should be routinely resected is still debatable

Aim(s): Endpoints of the study were the overall survival (OS) and the progression free survival (PFS) of pNETs, according to their clinical management.

Materials and methods: From 2009 to 2014 51 patients were newly diagnosed as having pNET. Among them, 15 patients with small (≤20 mm) pNETs underwent a 3-month follow-up for the first year and then biannual (FU). TNM stage was I in all but one patient (stage IIA). 21 patients underwent surgical resection (SR): TNM stage was I, IIA, IIIB, IV in two, nine, one, nine cases, respectively. 15 patients received systemic therapy (ST) due to advanced disease or contraindications to surgery; of them five, two and eight were at stage IIA; IIB and IV, respectively.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Rossi R

Authors: Massironi S, Rossi R, Zilli A, Conte D, Ciafardini C,

Keywords: pancreatic neuroendocrine tumor, prognosis,