Abstract Library

#1675 Abdominal Obesity, Fasting Glucose and Metabolic Syndrome Are Risk Factors for Well Differentiated Digestive Neuroendocrine Tumors

Introduction: Digestive NETs(DNETs)`s incidence has increased last 40 years. Visceral obesity and metabolic syndrome (MetSyn) were recently reported to be associated with several cancers, although not so far with DNET.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Santos A, Santos A, Castro C, Raposo L, Torres I,

Keywords: neuroendocrine tumors, metabolic syndrome, visceral obesity ,

#788 A Novel Animal Model for Medullary Thyroid Carcinoma

Introduction: Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer originating from calcitonin-producing C-cells. Surgical resection is the most effective treatment currently available. Understanding the molecular pathways mediating MTC is crucial for the development of novel therapies. Cyclin-dependent kinase 5 (Cdk5) and its activators, p35 and p25, have recently been implicated in MTC etiology. P25 is a cleavage product of p35 and the binding of p25 to Cdk5 leads to aberrant Cdk5 activity.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Pozo K, Castro-Rivera E, Tan C, Siegl V, Plattner F,

Keywords: thyroid, Cdk5,

#324 Well-differentiated Pancreatic Neuroendocrine Tumor of Uncertain Behavior: A Case Report

Introduction: A small number of Pancreatic Endocrine Tumors (PET) are well-differentiated tumors(WDET) showing benign or uncertain behavior. Prognosis mainly depends on the presence/absence of liver/bone metastasis.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Couto J, Santos A, Martins R, Castro F, Gomes D,

Keywords: pancreatic, neuroendocrine, tumor, uncertain, behavior, metastasis ,

#271 A Novel Missense Mutation of the TMEM127 Gene that Leads to Pheochromocytoma Phenotype

Introduction: Recently, truncating germline mutations in TMEM127 gene have been identified in 30% of familial cases of adrenal pheochromocytoma (PHEO) and in 3% of apparently sporadic cases.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Domingues R, Vilar H, Lopes L, Jácome de Castro J, Martins Bugalho M,

Keywords: pheochromocytoma, familial forms, germline mutations, susceptibility genes, TMEM127,