Abstract Library

#4600 Artificial intelligence in predicting neuroendocrine tumour (NET) outcomes: A model-based prognostic approach

Introduction: Neuroendocrine tumours (NETs) vary widely in clinical behaviour, complicating prognosis. Traditional models often struggle with accuracy due to the complexity of NETs. Artificial intelligence (AI) offers tools for enhanced prognostic precision by analysing complex datasets. This study explores an AI-driven approach to predict outcomes in NET patients at Cantonment General Hospital, Pakistan.

Conference:

Presenting Author: Fatima A

Authors: Fatima A,

Keywords: artificial intelligence, machine learning, Precision medicine, Personalised treatment,

#4587 Exploring the splicing landscape to identify survival-related biomarkers in small intestine neuroendocrine neoplasms

Introduction: The study of small intestine neuroendocrine neoplasms (siNENs) is challenging due to their rarity and complexity. While transcriptomic subtypes have been identified, the mechanisms behind their progression are still unclear. The process of RNA splicing is often altered in cancer, and our group has described that such dysregulation is also present in various NENs.

Conference:

Presenting Author: Ibáñez Costa A

Authors: Ibáñez-Costa A, García Vioque V, Pedraza-Arévalo S, Hernando Cubero J, García A,

Keywords: small intestine neuroendocrine tumour, splicing, biomarker, survival, ki-67, RNA,

#4549 Alpha-Fetoprotein as a valuable biomarker in neuroendocrine tumours

Introduction: Neuroendocrine tumours (NETs) are a rare group of tumours that pose a significant diagnostic, therapeutic, and prognostic challenge. This complexity arises from the diversity and heterogeneity of these neoplasms, as well as from the limitations of commonly used biomarkers in clinical practice. Alpha-fetoprotein (AFP) is a fetal protein widely used primarily for congenital defects in prenatal diagnostics and in certain malignancies in adults.

Conference:

Presenting Author:

Authors: Musiałkiewicz J, Gut P, Komarnicki P, Maciejewski A, Ruchała M,

Keywords: alpha-fetoprotein, biomarker, neuroendocrine tumour,

#4352 What can a reference centre offer to patients? Evolution of first visits for neuroendocrine and endocrine tumours and its relation to clinical trials availability.

Introduction: Endocrine and neuroendocrine neoplasia (NEN), which include gastroenteropancreatic neuroendocrine tumours, thyroid cancer and adrenal carcinoma, have a low incidence, making their diagnosis and treatment difficult. Due to this complexity, patients should be managed at specialised centres; however, the lack of official referral networks complicates the concentration of cases.

Conference:

Presenting Author: Martinez-Badal S

Authors: Martínez-Badal S, Hernando Cubero J, García Alvarez A, Elguero B, Alcantara A,

Keywords: Neuroendocrine, Clinical Trial, Reference Centre, Patient referral,

#4297 Small bowel neuroendocrine neoplasm – A very intriguing case

Introduction: Functional neuroendocrine neoplasms (NEN) frequently result in a range of severe and unpleasant symptoms and can also result in life threatening illness. This case report will detail the complex history of a patient with metastatic small bowel tumour diagnosed in 2015 with current stable disease treated at the West of Scotland Cancer Centre.

Conference:

Presenting Author: Wotherspoon I

Authors: Wotherspoon I,

Keywords: Neuroendocrine cancer, Complexity, Life threatening complications,