Abstract Library

#3252 Streptozotocin resistant pancreatic neuroendocrine tumor cell lines as a tool to understand chemotherapy resistance in pNET

Introduction: Streptozotocin based chemotherapy is standard of care in patients with advanced pancreatic neuroendocrine tumors (pNET). Although partial remission can initially be achieved in up to 40% of patients, primary non-responders and development of secondary progression under therapy is a major clinical challenge. So far, the mechanism leading to streptozotocin resistance have not been elucidated.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Schrader J

Authors: Viol F, Amin T, Fahl M, Izbicki J, Schrader J,

Keywords: streptozotocin, pNET, MGMT,

#2868 Differential Gene Expression May Predict Response to Somatostatin Analogues (SSAs) in Gastrointestinal (GI) Neuroendocrine Tumors (NETs)

Introduction: SSAs are commonly used to treat GI NETs as they have anti-secretory and antiproliferative effects. However, genetic markers predicting response to SSAs are lacking.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Teufel A

Authors: Teufel A, Evert K, Itzel T, Evert M, Koch C,

Keywords: NET gene expression profiling, SSA somatostatin analoga,

#954 Specific MicroRNA Profiles are Associated with Pathological Features in Lung Carcinoids

Introduction: Data on miRNA expression in lung carcinoids are scarce.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Volante M

Authors: Rapa I, Votta A, Felice B, Righi L, Giorcelli J,

Keywords: lung, carcinoid, miRNA,

#654 Identification of Signaling Pathways Involved in Lung Carcinoid Progression Using Gene Expression Profiling

Introduction: Lung carcinoids are well-differentiated neuroendocrine tumors (NETs) usually associated with a favorable prognosis. Mechanisms underlying progression are poorly understood.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Swarts D, Van Neste L, Henfling M, Eijkenboom I, Van Velthuysen M,

Keywords: bronchial carcinoids, cDNA microarray, chromosomal passenger complex, immunohistochemistry, progression,

#462 Genome-Wide Expression Profiling Reveals Downregulation of OTP and CD44 and Upregulation of RET as Indicators of Poor Prognosis in Lung Carcinoids

Introduction: Lung carcinoids comprise a heterogeneous group of neuroendocrine tumors. Only few parameters have been identified that correlated with poor disease outcome, including 11q22-q25 deletions. New biomarkers are required to further improve diagnosis and prediction of prognosis.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Swarts D, Van Neste L, Henfling M, Van Suylen R, Volante M,

Keywords: Bronchial carcinoids, cDNA microarray, MEN-2,