Abstract Library

#3367 Integrating Saffron’s Metabolomics on Neuroblastoma Treatment

Introduction: Crocus sativus (saffron) is endowed with anticancer, antioxidant and genoprotective properties. Its pharmacological properties are attributed to the hydrophilic carotenoids crocins (CRCs), which are glycosy-esters of crocetin (CRT). The hemisynthetic derivate dimethylcrocetin (DMCRT) is similar to CRT.

Conference:

Presenting Author:

Authors: Hatziagapiou K, Nikola O, Koniari E, Chrousos G, Kanaka-Gantenbein C,

Keywords: saffron, crocins, dimethylocrocetin, neuroblastoma, cytotoxicity, apoptosis,

#1320 Are eIFs Ingredients for Neuroendocrine Tumorigenesis?

Introduction: Neuroendocrine tumors (NETs) develop in almost any organ, therefore they are a very heterogeneous group of tumors. One of the major activities in every cell is the translation of mRNA to the corresponding protein, which plays an important role in cancer development. Crucial for this translation process are eukaryotic initiation factors (eIFs), which are themselves regulated by the mammalian target of Rapamycin (mTOR)-pathway. Mutation or deregulated expression of eIFs influences cell growth and proliferation, contributing to carcinogenesis. The incidence of NETs has increased fivefold over the last three decades.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Haybaeck J

Authors: Gantenbein N, Smolle E, Thalhammer M, Kornprat P, Lackner C,

Keywords: NETs, mTOR, eukaryotic translation initiation,