Abstract Library

#4206 Specific spliceosomic landscapes reveal a possible link between RNA processing and panNETs behaviour

Introduction: Pancreatic Neuroendocrine Tumors (PanNETs) are characterized by a low number of mutations. Despite genomics, transcriptomics and epigenomics studies have helped to understand the molecular features of PanNETs, there is still a vast unexplored ground for better comprehension of this disease. In this context, we have previously documented that RNA splicing is dysregulated in these tumors, which unveils new avenues to discover potential biomarkers and therapeutic targets. However, clinical and molecular implications of this dysregulation are still very poorly understood.

Conference:

Presenting Author: Pedraza-Arévalo S

Authors: Pedraza-Arévalo S, Blázquez-Encinas R, García-Vioque V, Moreno-Montilla M, Ruiz-Palacios D,

Keywords: pancreatic neuroendocrine tumor, splicing, RNA, grade, metastasis,

#3568 Exploring the interplay between chromatin-remodeling genes and the regulation of alternative splicing and RNA biology in lung neuroendocrine neoplasms

Introduction: Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of rare tumors, but with a rising incidence in the last decades. The mutational landscape of LungNENs has been recently described; in contrast, other key regulatory mechanisms, particularly posttranscriptional processes linked to RNA regulation, remain largely unexplored.

Conference:

Presenting Author: Agraz-Doblas A

Authors: Agraz-Doblas A, Blázquez-Encinas R, Victor G, Alcala N, Sexton-Oates A,

Keywords: Lung NEN, Bioinformatics, Chromatin-remodeling, RNA, biomarker, mutations,

#3521 Molecular, histopathological, and functional characterization of the dysregulation of the splicing machinery in lung carcinoids

Introduction: Alteration of alternative splicing is an emerging hallmark of cancer, which has been linked to aggressiveness features in diverse types of tumors, including neuroendocrine neoplasms.

Conference:

Presenting Author: García Vioque V

Authors: García-Vioque V, Blázquez-Encinas R, Caro-Cuenca T, Moreno-Montilla M, Alors-Pérez E,

Keywords: lung carcinoid, splicing dysregulation, splicing events, splicing machinery,

#3509 Comparative biocomputational analysis of the splicing landscape across lung neuroendocrine neoplasms unveils a new actionable molecular layer

Introduction: Dysregulation of alternative splicing has emerged as a new, overarching hallmark of cancer, which may arise from mutations and/or altered expression of specific components of the splicing machinery. To date, no studies have been reported comparing the spliceosomic landscape, i.e. the status of the splicing machinery and alternative splicing patterns, among the different histological types of pulmonary neuroendocrine neoplasms (LungNENs), namely typical and atypical pulmonary carcinoids, Large Cell Neuroendocrine Carcinoma (LCNEC) and Small Cell Lung Cancer (SCLC).

Conference:

Presenting Author: Blázquez-Encinas R

Authors: Blázquez-Encinas R, García-Vioque V, Sexton-Oates A, Moreno-Montilla M, Alors-Pérez E,

Keywords: Neuroendocrine, NEN, Lung, Splicing,

#3493 Molecular characterization of the splicing machinery in pheochromocytomas and paragangliomas unveils a marked dysregulation with instructive potential

Introduction: Pheochromocytomas and paragangliomas(PPGL) are rare neuroendocrine neoplasms. Up to 25% will develop distant metastases or aggressive behaviour, but there is a lack of accurate risk markers able to stratify patients according to their potential outcome. Genomic characterization of PPGLs has identified 3 clusters: Pseudohypoxic-profile, MAPK-pathway alteration, and Wnt-pathway dysregulation. Alternative splicing dysregulation is emerging as a novel hallmark of cancer, due to its link to oncogenesis and aggressiveness in different neoplasms, including NENs.

Conference:

Presenting Author:

Authors: Moreno-Montilla M, Encinas Rey R, Martínez Montes A, García-Vioque V, Alors-Pérez E,

Keywords: pheochromocytoma, paraganglioma, metastasis, splicing dysregulation, splicing machinery,