Abstract Library

#4649 Claudin 18.2 overexpression in gastric neuroendocrine tumours

Introduction: Claudin 18.2, is a tissue biomarker physiologically expressed in both healthy gastric mucosa and gastric adenocarcinoma which represents a novel therapeutic target advanced gastric cancer. Various other cancers showed some overexpression of claudin 18.2 opening potential opportunities to agnostic targeted therapy. However, data about claudin 18.2 expression in NENs are poor with only an Eastern study showing higher rate of claudin 18.2 positivity in GEP-NENs, mainly from gastric primary site (27.8%).

Conference:

Presenting Author: Gervaso L

Authors: Gervaso L, Lobrano R, Pisa E, Benini L, Spada F,

Keywords: claudin, gastric NET, biomarker, Neuroendocrine tumour,

#4200 Risk of venous thromboembolism according to molecular profiling in patients with neuroendocrine carcinoma

Introduction: Venous thromboembolism (VTE) is a common complication in cancer patients, which negatively affects prognosis. Neuroendocrine carcinomas (NEC) are a rare and aggressive diseases, with low responses to treatment and poor prognosis. In this context, the use of molecular profiling is crucial for the identification of druggable alterations. However, data about VTE in NENs are scares, even though retrospective data describes rates in line with other high-risk malignancies.

Conference:

Presenting Author:

Authors: Gervaso L, Winchler C, Pisa E, Benini L, Cella C,

Keywords: VTE, NEC, molecular profiling, neuroendocrine carcinoma, venous thromboembolism,

#3888 Outcome of typical and atypical carcinoids after surgical resection – A single center retrospective study

Introduction: Typical (TC) and atypical carcinoids (AC) are rare malignant neoplasms.

Conference:

Presenting Author: Rubino M

Authors: Rubino M, Girelli L, Pisa E, Gervaso L, Spada F,

Keywords: lung carcinoid, primary surgery, recurrence rate, overall survival,

#3846 Poorly differentiated neuroendocrine carcinomas – Characteristics, treatments and outcomes from a population-based cohort discussed in our ENETS-CoE institute

Introduction: Poorly differentiated neuroendocrine carcinomas (NECs) are rare malignancies with a dismal prognosis, few therapeutic options available and lacking predictive factors.

Conference:

Presenting Author: Benini L

Authors: Benini L, Spada F, Gervaso L, Borghesani M, Rubino M,

Keywords: Neuroendocrine Carcinoma, NEC,

#3821 Risk of venous thromboembolism in pancreatic neuroendocrine neoplasms

Introduction: Venous thromboembolism (VTE) is a leading cause of morbidity and death in cancer. The incidence of VTE is increased in different cancers such as pancreatic ductal adenocarcinoma, however limited evidence is present this risk for pancreatic neuroendocrine neoplasms (pan-NENs).

Conference:

Presenting Author: Gervaso L

Authors: Gervaso L, Laffi A, Cella C, Rubino M, Spada F,

Keywords: Venous thromboembolism, pancreatic neuroendocrine tumor, pancreatic neuroendocrine carcinoma, NEN, VTE,