Abstract Library

#2861 Targeted Next Generation Sequencing Analysis Reveals the Genetic Characteristics of Gastric Neuroendocrine Neoplasmas

Introduction: there are abundant information about the clinical therapy and pathological features of gastric neuroendocrine neoplasms (gNENs) but little about its genetic characteristics.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Chen H

Authors: Huang C, Yanfen S, Yuanliang L, Xiaowei W, Huangying T,

Keywords: gastric neuroendocrine neoplasms, SNV, CNV,

#2781 Case Report: Whole Exon Sequencing of Primary Lesion and Metastatic Liver Lesion in Pancreatic Neuroendocrine Tumor

Introduction: Pancreatic neuroendocrine neoplasms(NENs) are classified into neuroendocrine tumors (NET) G1, G2, G3, and neuroendocrine carcinoma (NEC), which are different pathogenesis. The two kinds of tumors that occurs in the same lesion in one patient is very rare. We found high grade neuroendocrine neoplasms(NENG3) with a diameter of 0.1 cm in a patient with a pancreatic NETG2 (1.7 cm in diameter). The cells were significant atypia with Ki67 index of 60%, focal necrosis, while metastatic nodules in the liver (12, 0.1-1.1 cm in diameter) were all high grade NENG3.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Shi Y, Zhong D, Li Y, Niu Y, Tan H,

Keywords: pancreatic neuroendocrine neoplasms, whole exon sequencing, TRIOBP signaling pathway, MDM4,

#2683 Clinicopathological Features and Prognostic Analysis of 227 Cases with Well-Differentiated Gastric Neuroendocrine Tumors

Introduction: Gastric neuroendocrine neoplasms (g-NENs) are a group of rare tumors with a strong heterogeneity, subdivided as well-differentiated neuroendocrine tumors (NETs, type 1-3 g-NETs) and poorly-differentiated neuroendocrine carcinoma(NECs). WHO classification(2019) for digestive system tumours has carried out a new classification and grading criteria for NENs of the gastrointestinal tract recently, there is very few relevant clinical data based on this new classification, especially for gastric NETs(g-NETs).

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Li Y, Tan H, Jie C, Jie L, Pan Z,

Keywords: clinicopathological features, prognostic analysis, well-differentiated gastric neuroendocrine tumors, grade, type,

#1468 Evaluation of ENETS and AJCC Staging Systems for Pancreatic Neuroendocrine Neoplasms: A Multicenter Study in China.

Introduction: Accurate staging system is crucial for p-NENs management. The European Neuroendocrine Tumor Society (ENETS) and the International Union for Cancer Control/ American Joint Cancer Committee/ World Health Organization (UICC/AJCC/WHO) advocated their TNM staging system for pancreatic neuroendocrine neoplasms (p-NENs) respectively.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Jin K

Authors: Jin K, Zhang Y, Luo G, Sun J, Tan H,

Keywords: p-NENs, AJCC, ENETS, TNM Staging System,

#1439 Sunitinib in the Treatment of Unresectable or Metastatic Gastroenteropancreatic Neuroendocrine Neoplasm: A Multicenter Retrospective Study in China

Introduction: Sunitinib has shown activity against pancreatic neuroendocrine tumors(NEN) in a global phase III clinical trial.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Jie C

Authors: Yuhong W, Huangying T, Kaizhou J, Qiuchen Y, Jie L,

Keywords: gastroenteropancreatic neuroendocrine neoplasm, sunitinib, treatment,