Abstract Library

#4358 Patients with neuroendocrine tumour after surgical treatment and therapy with somatostatin analogues: Comparison of body mass index (BMI)

Introduction: Neuroendocrine tumours (NET) are heterogeneous neoplasms, commonly arising in the gastroenteropancreatic tract (GEP-NET) or bronchopulmonary (L-NET). Surgery is the first line treatment, when possible, while somatostatin analogues (SSA) are the main medical therapy. However, the impact of these therapies on anthropometric indices has not been fully explored.

Conference:

Presenting Author:

Authors: Di Iasi G, Benevento E, Cannavale G, Di Nola M, Liccardi A,

Keywords: BMI, NET, SSA, SURGERY, WEIGHT LOSS, GEP-NET, LUNG NET, WAIST CIRCUMFERENCE, HIP CIRCUMFERENCE,

#4214 Splenic metastases in the course of neuroendocrine tumors – Are they really that uncommon?

Introduction: Splenic metastases are described as exceptional in the literature. Their frequency is low regardless of the type of neoplasm. In the course of neuroendocrine tumors (NETs), spleen involvement seems infrequent too. There is only a limited number of case reports of such presentation.

Conference:

Presenting Author:

Authors: Maciejewski A, Komarnicki P, Wietrzyk D, Musiałkiewicz J, Woliński K,

Keywords: NETs, metastases, spleen, clinical course,

#4208 The somatostatin system – A silent messenger in pheochromocytomas and paragangliomas?

Introduction: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine neoplasms (NENs) arising from neural crest-derived chromaffin cells. Due to the abundance of somatostatin receptors (SSTs) on the surface of most NENs, somatostatin analogues (SSAs) have become a cornerstone in their diagnosis and treatment. However, while PPGLs exhibit this feature, their functional responsiveness to SSAs remains limited, with the underlying cause of this resistance being still elusive.

Conference:

Presenting Author:

Authors: García Vioque V, Moreno-Montilla M, Blázquez-Encinas R, Barlier A, Arroba E,

Keywords: pheochromocytomas, paragangliomas, neuroendocrine tumor, somatostatin analogues, treatment resistance,

#3952 Peptide Receptor Radionuclide Therapy (PRRT) in the management of patients with ectopic Cushing’s syndrome due to metastatic gastroenteropancreatic neuroendocrine neoplasia (GEPNEN): A single centre experience

Introduction: Metastatic GEPNEN can cause ectopic Cushing’s syndrome (ECS). ECS is highly morbid and often refractory to medical therapy. Bilateral adrenalectomy (BA) carries risk and long-term morbidity. Patients (pts) unsuitable for surgery have dismal outcomes. Peptide receptor radionuclide therapy (PRRT) is a rational option for hormone control in ECS caused by NEN with high somatostatin receptor (SSTR) expression yet detailed case series to guide its use are lacking.

Conference:

Presenting Author: Boehm E

Authors: Boehm E, Hung T, Akhurst T, Alipour R, Cardin A,

Keywords: GEPNEN, PRRT, Ectopic Cushing's Syndrome,

#3844 Post-partum insulinoma in a MEN1 patient submitted to pancreatic electroporation

Introduction: Pancreatic neuroendocrine tumors (panNET) are a frequent manifestation of MEN1 syndrome. Insulinomas are often surgically treated.

Conference:

Presenting Author: Gil-Santos S

Authors: Gil-Santos S, Santos A, Carvalho A, Oliveira J, Souteiro P,

Keywords: insulinoma, electroporation, pancreatic neuroendocrine tumor, MEN1,