Abstract Library

#4163 Metabolite biomarker discovery for pancreatic neuroendocrine tumors using metabolomic approach

Introduction: Metabolic flexibility is one of the key hallmarks of cancer and metabolites are the final products of this adaptation, reflecting the tumors’ aberrant changes. However, the metabolic plasticity of pancreatic neuroendocrine tumors (pNET) is still unknown. pNETs are heterogeneous which makes their diagnosis, prognosis and therapeutic management difficult.

Conference:

Presenting Author:

Authors: Jannin A, Dessein A, Dabo S, Descat A, Vantyghem M,

Keywords: pancreatic NET, diagnostic biomarker, plasma metabolites, molecular pathways,

#4125 Durvalumab (D) plus Tremelimumab (T) for the treatment of patients with progressive, advanced medullary thyroid carcinoma (MTC) – DUTHY (GETNE-T1812) trial

Introduction: Evidence for immunotherapy (IT) in patients (pts) with MTC is limited and has shown modest activity.

Conference:

Presenting Author:

Authors: García-Álvarez A, Molina-Cerrillo J, Castelo B, Plana M, Iglesias L,

Keywords: Medullary thyroid carcinoma, Immunotherapy, durvalumab, tremelimumab, anti PD-L1, anti CTLA-4,

#4111 Relationship between absorbed dose and response in neuroendocrine tumors treated with [177Lu]Lu-DOTA-TATE

Introduction: Peptide receptor radionuclide therapy (PRRT) presents the possibility of tracing and quantifying the uptake of the drug in the body and performing dosimetry, potentially allowing individualization of treatment schemes. However, the details of how neuroendocrine tumors (NETs) respond to different absorbed doses are insufficiently known.

Conference:

Presenting Author: Warfvinge C

Authors: Warfvinge C, Gustafsson J, Roth D, Tennvall J, Svensson J,

Keywords: PRRT, Neuroendocrine tumor, dose-response, dosimetry,

#3708 A strange biodistribution of 68Ga-DOTATOC PET/CT in a NET patient – Do you have some advice?

Introduction: We report the case of an abnormal distribution of Ga-68-DOTATOC PET/CT in a NET patient.

Conference:

Presenting Author: Grana C

Authors: Grana C, Gilardi L, Travaini L, Fracassi S, Muraglia L,

Keywords: Ga-68-DOTATOC PET/CT, GEP-NET, abnormal biodistribution, case report,

#3458 Post-PRRT imaging: Which scans to make and what to look for

Introduction: Post-PRRT imaging often focuses on dosimetry but seldom on its clinical utility.

Conference:

Presenting Author: Aalbersberg E

Authors: Aalbersberg E, Huizing D, Tesselaar M, Stokkel M, Versleijen M,

Keywords: PRRT,