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#4079 Temporal increase in Ki-67 index in patients with pancreatic neuroendocrine tumors (PanNETs): Frequency, prognostic impact, and causal factors

Introduction: PanNETs show intra-tumor heterogeneity, notably regarding Ki-67 index which is a major prognostic biomarker. Temporal heterogeneity and its prognostic impact have been poorly explored so far.

Conference:

Presenting Author: Bourdeleau-Guerry P

Authors: Bourdeleau-Guerry P, Pokossy-Epée J, Hentic O, Couvelard A, Ruszniewski P,

Keywords: neuroendocrine tumor, Ki-67 index, tumor grade, temporal evolution, molecular evolution, biologic evolution,