#4111
Relationship between absorbed dose and response in neuroendocrine tumors treated with [177Lu]Lu-DOTA-TATE
Introduction:
Peptide receptor radionuclide therapy (PRRT) presents the possibility of tracing and quantifying the uptake of the drug in the body and performing dosimetry, potentially allowing individualization of treatment schemes. However, the details of how neuroendocrine tumors (NETs) respond to different absorbed doses are insufficiently known.
Conference:
Presenting Author:
Warfvinge C
Authors:
Warfvinge C,
Gustafsson J,
Roth D,
Tennvall J,
Svensson J,
Keywords:
PRRT,
Neuroendocrine tumor,
dose-response,
dosimetry,
#2280
The BON-SSTR2 Chicken Chorioallantoic Membrane (CAM) Model for the Analysis of Lu-17-DOTATOC Sensitizing Agents
Introduction:
Peptide radioreceptor therapy (PRRT) is a promising therapy option for SSTR2-positive pancreatic neuroendocrine neoplasms (NEN). However, therapeutic effects are often not satisfying concerning sensitivity to PRRT. We hypothesize that the slow proliferation of NENs provides sufficient time for the repair of beta-particle induced-DNA damage. The ubiquitin-proteasome-system is involved in DNA damage repair and affected by the proteasome inhibitor bortezomib (Velcade®). The inhibition of DNA damage repair during PRRT may be an option to improve therapy response in NEN. We have recently demonstrated the damage repair inhibitory and pro-apoptotic effect of bortezomib in NEN in vitro (Briest et al., in revision).
Conference:
15th Annual ENETSConcerence (2018)
Presenting Author:
Briest F
Authors:
Briest F,
Grötzinger C,
Exner S,
Sedding D,
Baum R,
Keywords:
peptide radioreceptor therapy,
Lu-177-DOTATOC,
PRRT,
bortezomib,
in vivo model,
SPECT/CT Imaging,
chicken CAM model,
Sensitizer,
DNA damage repair,
#1057
Localisation of Insulinoma and Beta-Cells: Comparison of Glucagon-Like Peptide-1 Receptor (GLP1-R) SPECT/CT, PET/CT and MRI. Preliminary Results of a Prospective Clinical Study.
Introduction:
SPECT/CT imaging with GLP1-R specific radiotracers like 111In-DOTA-exendin-4 have already proved to be a useful tool for the preoperative localisation of insulinomas. PET/CT has several advantages over SPECT/CT: lower radiation exposure, less time consumption and higher spatial resolution.
Conference:
12th Annual ENETSConcerence (2015)
Presenting Author:
Authors:
Rottenburger C,
Antwi K,
Heye T,
Fani M,
Nicolas G,
Keywords:
Insulinoma,
Nesidioblastosis,
Glucagon-like Peptide-1 Receptor,
PET/CT,
SPECT/CT,
