Abstract Library

#3934 The stromal microenvironment endows pancreatic neuroendocrine tumors with spatially specific invasive and metastatic phenotypes

Introduction: Cancer-associated fibroblasts (CAFs) play an important role in a variety of cancers. However, the heterogeneity of CAFs is poorly understood in non-functional pancreatic neuroendocrine tumors (NF-PanNETs). Profiling the heterogeneity of CAFs might reveal the causes of malignant phenotypes in NF-PanNETs.

Conference:

Presenting Author: Ye Z

Authors: Ye Z, Zhou C, Xu X, Chen J, Yu X,

Keywords: nonfunctional pancreatic neuroendocrine tumors, TGF-β, epithelial-mesenchymal transition,

#3713 Methylmalonic acid activates INHBA induced epithelial-mesenchymal transition and promotes the cancer progression by TGF-β signalling pathway in pancreatic neuroendocrine neoplasm

Introduction: Metabolic reprogramming is a well-recognized hallmark of cancer progression, especially the process of tumor metastasis. However, the role of metabolic alteration and its potential mechanism in pancreatic neuroendocrine neoplasm (pNEN) with metastasis remain elusive.

Conference:

Presenting Author: Hu C

Authors: Hu C, Ye M, Bai J, Tang Q,

Keywords: metabolic reprogramming, pancreatic neuroendocrine neoplasm, methylmalonic acid, INHBA, TGF-β, epithelial-mesenchymal transition,

#3320 TGF-β increase caspase activation and migration in typical bronchial carcinoids

Introduction: Typical bronchial carcinoids (TBC) are well-differentiated neuroendocrine neoplasms (NEN) whose management can still be very challenging due to reduced sensitivity to therapy. Previous studies have reported TGF-β’s ability to activate mTOR pathway and induce epithelial to mesenchymal transition (EMT). Moreover, preliminary results show an overexpression of TGF-β signalling and caspase activation in TBC.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Gagliardi I

Authors: Borges de Souza P, Gagliardi I, Martelli M, Zatelli M,

Keywords: bronchial carcinoid, TGF-β signalling, mTOR, EMT,

#2983 Differential TGF-β Signalling in Typical and Atypical Bronchial Carcinoids

Introduction: Typical and atypical bronchial carcinoids (TBC and ABC) are well-differentiated neuroendocrine neoplasms (NEN). Metastatic BC having low to moderate mitotic count may still be treated with somatostatin analogues and mTOR inhibitors; however, TBC and ABC have been reported to respond very differently to therapy and an effective treatment algorithm is still lacking. TGF-β is known for its ability to activate mTOR pathway and induce epithelial mesenchymal transition, affecting cell pathophysiological capabilities such as proliferation, migration and tissue invasiveness.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Borges de Souza P

Authors: Borges de Souza P, Tagliatti V, Capobianco S, Ambrosio M, Chinnici S,

Keywords: Neuroendocrine neoplasms, bronchial carcinoids, TGF-β,