Abstract Library

#757 Circulating Endothelial Cells in Neuroendocrine Tumors

Introduction: Circulating endothelial cells (CECs) are mature endothelial cells that are shed into the bloodstream. We hypothesised that neuroendocrine tumors (NETs), being highly vascular, may shed more CECs into the circulation, and that changes in their number may serve as a biomarker for anti-angiogenic therapy.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Mandair D, Khan M, Lowe H, Griffin N, Tsigani T,

Keywords: biomarker,

#250 Circulating Tumor Cells (CTCs) Correlate with Overall Survival in Neuroendocrine Tumors (NETs)

Introduction: Using the CellSearchTM system, circulating tumor cells (CTCs) can be reproducibly enumerated. We have previously shown that CTCs are detectable in NETs and associated with progressive disease.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Khan M, Tsigani T, Garcia-Hernandez J, Caplin M, Meyer T,

Keywords: neuroendocrine tumor, circulating tumor cells, carcinoid, survival,

#88 EpCam expression and detection of circulating tumor cells in neuroendocrine tumors

Introduction: Using the CellSearchTM system, circulating tumor cells (CTCs) can be reproducibly enumerated according to expression of EpCAM and cytokeratins 8, 18 or 19 and the absence of the haemopoietic marker CD45. The number of CTCs detected in 7.5 mls blood has been shown to correlate with prognosis in breast, colon and prostate cancer and can predict response to therapy. Neuroendocrine tumors (NETs) have not previously been reported to express EpCAM and have not been systematically assessed for presence of CTCs. We have therefore explored the expression of EpCAM in NETs and the detection of NET cells in the circulation.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Khan M

Authors: Khan M, Tsigani T, Rashid M, Luong T, Caplin M,

Keywords: neuroendocrine tumor, circulating tumor cells, carcinoid, EpCAM,