Abstract Library

#757 Circulating Endothelial Cells in Neuroendocrine Tumors

Introduction: Circulating endothelial cells (CECs) are mature endothelial cells that are shed into the bloodstream. We hypothesised that neuroendocrine tumors (NETs), being highly vascular, may shed more CECs into the circulation, and that changes in their number may serve as a biomarker for anti-angiogenic therapy.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Mandair D, Khan M, Lowe H, Griffin N, Tsigani T,

Keywords: biomarker,

#722 Isolation and Whole Genome Amplification of Single Circulating Tumor Cells in Neuroendocrine Tumors: A Pilot Study

Introduction: We have previously demonstrated that Circulating Tumor Cells (CTCs) can be detected in patients with neuroendocrine tumors (NET) and that their presence is prognostic. Downstream analysis of CTCs provides an opportunity to explore their potential as biomarker for targeted therapy. Here we present initial data which demonstrates that molecular profiling can be successfully performed on single CTCs from patients with NETs

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Mandair D, Karpathakis A, Lowe H, Griffin N, Caplin M,

Keywords: circulating tumor cells, biomarker,