Abstract Library

#4166 Characterising the tumor microenvironment of multifocal small intestinal NETs

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) are thought to arise from enterochromaffin cells of the gut, often with multiple synchronous primary tumors. Recently, we showed that synchronous primary tumors from the same SI-NET patient display distinct somatic mutational profiles, suggesting that these tumors originate independently, despite few clear driver mutations. Thus, new mechanistic insights into multifocal SI-NETs are urgently needed.

Conference:

Presenting Author:

Authors: Mäkinen N, Lee I, Dohlman A, Gao T, Zhang Z,

Keywords: small intestinal NET, tumor microenvironment, tumor microbiome,

#4061 Dissecting the single-cell transcriptome network underlying thymic neuroendocrine tumor and thymus non-malignant tissues

Introduction: Thymic neuroendocrine tumor (TNET) is the rarest subtype among thymic epithelial tumors and NET. Limited understanding of tumor microenvironment (TME) of TNET contributes to the lack of treatment options for this rare tumor type.

Conference:

Presenting Author: Liu M

Authors: Liu M, Lin X, Chen L, Su C, Wen W,

Keywords: thymic neuroendocrine tumor, single-cell RNA sequencing, tumor microenvironment, tumor-associated fibroblasts,

#3883 Immune landscape in mixed neuroendocrine-non neuroendocrine neoplasms (MiNEN)

Introduction: A mixed neuroendocrine-non neuroendocrine neoplasm (MiNEN) is a novel defined rare entity, made up of two morphologically distinct neoplastic components; one neuroendocrine type (NEN), and the other one non-neuroendocrine type (nNEN). Neuroendocrine differentiation of tumors is thought to influence the tumor microenvironment (TME) through the secretion of various hormones or growth factors.

Conference:

Presenting Author:

Authors: Di Mauro A, Ferrara G, Iervolino D, Scognamiglio G, Clemente O,

Keywords: mixed neuroendocrine, neuroendocrine, tumor microenvironment, immunotherapy, biomarker,

#3796 The effect of pseudohypoxia on the immune microenvironment of pancreatic neuroendocrine neoplasms (PanNEN)

Introduction: Pancreatic neuroendocrine tumors may develop sporadically or as part of an inherited disease, such as von Hippel-Lindau (VHL). VHL disease is caused by a germline pathogenic variant in the VHL gene encoding VHL protein (pVHL). Hypoxia inducible factor (HIF) is responsible for cellular oxygen supply. Its degradation is mediated in normoxic states via ubiquitination and inhibited by pVHL. Hence, pVHL deficiency leads to pseudohypoxia due to HIF overexpression. Several studies suggested immunomodulatory role for HIF in kidney cancer.

Conference:

Presenting Author:

Authors: Solomon Chmelnik A, Telerman A, Tirosh A,

Keywords: Pancreatic neuroendocrine tumor, VHL, DNA methylation, Immune cells, PD-L1,

#3793 Decellularised pancreas explants as a novel 3D model for pancreatic neuroendocrine tumors (PNETs) biomarker discovery

Introduction: The lack of preclinical models of pancreatic neuroendocrine tumors (pNETs) challenges advancement in biomarker discovery. Culturing cancer cells in their native tissue enables the study of complex tumor cell-ECM interactions, products of which could be utilised as disease biomarkers.

Conference:

Presenting Author: Ney A

Authors: Ney A, Al-Akkad W, Sedlak E, Garcia-Sampedro A, Hall A,

Keywords: Disease model, Tumor microenvironment, Biomarker discovery, Pancreatic NET,