Abstract Library

#3579 Setting up of a national liver transplant programme for neuroendocrine tumor liver metastases in UK and Ireland: Opportunities for collaborations in clinical study and research

Introduction: Liver transplantation [LT] for unresectable neuroendocrine tumor liver metastases [NET LM] is one of three new cancer indications in UK and Ireland. Transplant benefit is only proven using the Milan criteria so patient selection needs to be meticulously objective. We have therefore created a national MDT to provide a formal framework, aid patient selection, oversee data collection, monitor performance, provide training and education, deliver equity of access, facilitate research and clinical trials.

Conference:

Presenting Author:

Authors: Shah T, Gibbs P, Moore J, Venkataraman H, O'Toole D,

Keywords: liver transplantation, neuroendocrine tumor liver metastasis, neuroendocrine tumor surgery,

#3339 Approval of a programme to perform 50 liver transplants for neuroendocrine tumor liver metastases in UK and Ireland affords significant opportunities for clinical study and research

Introduction: Liver transplantation for unresectable neuroendocrine tumor liver metastases [NET LM] remains a confusing and controversial area in managing NETs. Patients deemed most suitable for transplantation have good prognosis with standard therapy and best outcomes with transplantation are only achieved at highly experienced Centre(s).

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Shah T

Authors: Shah T, Gibbs P, Moore J, Venkataraman H, O'Toole D,

Keywords: neuroendocrine tumor, unresectable liver metastases, liver transplantation, Milan Criteria,

#3082 MEN1 Associated pNETs: A Case Series from Two Centres of Excellence in the United Kingdom

Introduction: Literature on MEN1 associated PNETS as a unique clinico-pathological entity is evolving.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Venkataraman H

Authors: Venkataraman H, Hegde P, Purewal T, Smith S, Vicarage S,

Keywords: Pancreatic neuroendocrine tumors, Multiple endocrine neoplasia, sporadic pancreatic neuroendocrine tumors,

#2833 Surgical Correction of Carcinoid Heart Disease Improves Liver Function and 5-Hydroxyindoleacetic Acid Levels

Introduction: Neuroendocrine tumours of the gastrointestinal tract cause carcinoid syndrome and carcinoid heart disease. These tumours secrete serotonin, which can bind to heart valves and cause fibrosis and valve incompetence. Most cases involve the tricuspid valve +/- pulmonary valve. Medical management comprises diuretics for fluid overload and somatostatin analogues to reduce circulating serotonin. Definitive treatment is heart-valve replacement surgery which improves exercise tolerance but has high perioperative mortality. We have previously reported that valve-replacement surgery can reduce 5-hydroxyindoleacetic acid (5-HIAA) levels, reflecting a decline in hormone activity.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Shah H

Authors: Shah H, Sagar V, Venkataraman H, Steeds R, Rooney S,

Keywords: carcinoid, carcinoid syndrome, neuroendocrine tumour, carcinoid heart disease, 5hiaa,